DNA polymerase-IN-7
DNA polymerase-IN-7 is a noncompetitive inhibition of DNA Polymerase β with an IC50 of 112 nM and a Ki of 35 nM. DNA polymerase-IN-7 can inhibit DNA pol β lyase activity and the binding of the lyase domain of Pol β to DNA. DNA polymerase-IN-7 can be used for the research of cancer, such as cervical cancer.
For research use only. We do not sell to patients.
- Formula: C47H48N7O10P
- Molecular Weight:901.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
|
Rat pol β 112 nM (IC50) |
DNA Polymerase |
Rat pol β 35 nM (Ki) |
DNA polymerase-IN-7 (Compound 28) (0.1-1 μM) inhibits dGTP incorporation activity of DNA polymerase β (Pol β) and inhibits the lyase activity of Pol β[1].
DNA polymerase-IN-7 (0.35-2 μM) exerts little effect on the binding of Pol β to DNA, but inhibits the binding of the lyase domain of Pol β to DNA[1].
DNA polymerase-IN-7 (0.1-1 μM) exhibits selectivity for X-family polymerases, with inhibitory rate of 50% for Pol β and 41% for Pol λ at 0.1 μM, and almost 100% at 1 μM[1].
DNA polymerase-IN-7 (0-100 μM, 24 h) shows no obvious cytotoxicity, maintaining cell viability at 95-100% in HeLa cells[1].
DNA polymerase-IN-7 (25 μM, 24 h) shows intracellular concentration reaching 4.0 μM in HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 901.90
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Formula C47H48N7O10P
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SMILES
O=C(C1=CC=C(C2=CC=C(C3=CC=C(C4=CC=C(O)C=C4)C=C3)C=C2)C=C1)N[C@H]5C[C@H](N6C=C(CCCNC(C7=CN8C(C=C(C)C=C8)=N7)=O)C(NC6=O)=O)O[C@@H]5COP([O-])(OC)=O.[NH4+]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DNA polymerase-IN-7 Related Classifications
HY-178063 Related Classifications
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