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Retinol Binding Protein 4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Transthyretin (TTR) (2) Lipocalin Family (6) Reference Standards (1)
By Research Areas:	Cardiovascular Disease (1) Metabolic Disease (6) Neurological Disease (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: Emopamil Binding Protein Cdc42-binding kinase FKBP YB-1 Penicillin-binding protein (PBP) ATP-binding cassette (ABC) transporters FABP Oxysterol-binding Protein-related Protein (ORP) Transthyretin (TTR) Ligands for Target Protein for PROTAC SDCBP GHR P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107633

A 1120 1 Publications Verification	Transthyretin (TTR)	Metabolic Disease
A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a K_i value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin .

HY-143793

RBP4 inhibitor 1	Lipocalin Family	Metabolic Disease
RBP4 inhibitor 1 (compound 43b) is a potent and orally active retinol-binding protein 4 (RBP4) inhibitor with IC₅₀s of 28 nM and 110 nM for human and mouse RBP4. RBP4 inhibitor 1 has a potent and long-lasting blood RBP4-level-reducing effect in mice .

HY-123623

Tinlarebant LBS-008; BPN-14967	Lipocalin Family	Others
Tinlarebant (LBS-008) is an orally active non-retinoid RBP4 (retinol-binding protein 4) antagonist. Tinlarebant can be used for the research of the Stargardt disease .

HY-172232

STG-001	Lipocalin Family	Neurological Disease
STG-001 is a retinol binding protein 4 (RBP4) antagonist. STG-001 inhibits RBP4 to reduce the synthesis of retinal and diretinol, thereby preventing photoreceptor degeneration. STG-001 can be used in the study of sexually precocious nephropathy (STGD) .

HY-147366

RBP4 ligand-1	Lipocalin Family	Metabolic Disease
RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4_SPA IC₅₀ and RBP4-TTR FRET IC₅₀ values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively .

HY-185133

RBP4-IN-3	Lipocalin Family	Cardiovascular Disease Metabolic Disease
RBP4-IN-3 (Compound 38) is a retinol-binding protein 4 (RBP4) inhibitor. RBP4-IN-3 can be used in studies related to cardiovascular diseases and obesity.

HY-182385

BPN-14136	Lipocalin Family	Metabolic Disease
BPN-14136 is an orally effective retinol-binding protein 4 (RBP4) inhibitor. BPN-14136 inhibits the binding of retinol to RBP4 with an IC₅₀ of 12.8 nM. BPN-14136 inhibits retinol-dependent RBP4-transthyretin interaction (IC₅₀ = 43.6 nM) and reduces circulating plasma RBP4 levels in vivo. BPN-14136 decreases the formation of cytotoxic bisretinoids in retinal pigment epithelial cells. BPN-14136 can be used for the research of atrophic age-related macular degeneration and Stargardt disease .

HY-107633R

A 1120 (Standard)	Transthyretin (TTR) Reference Standards	Metabolic Disease
A 1120 (Standard) is the analytical standard of A 1120 (HY-107633). This product is intended for research and analytical applications. A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a K_i value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin .

Species:	Human (1) Cynomolgus (1)
Tag:	His (1) Tag Free (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70471

	RBP4 Protein, Human Retinol-Binding Protein 4; Plasma Retinol-Binding Protein; PRBP; RBP; RBP4	Human	E. coli
	RBP4 protein acts as a retinol-binding protein, essential for transporting retinol in blood plasma. It facilitates the delivery of retinol from the liver to peripheral tissues and likely transfers bound all-trans retinol to STRA6 for cell membrane transport. Interactions with TTR prevent kidney glomeruli filtration loss. Direct interaction with STRA6 underscores RBP4's role in intricate retinol transport and distribution processes in the body. RBP4 Protein, Human is the recombinant human-derived RBP4 protein, expressed by E. coli , with tag free.

HY-P77171

	RBP4 Protein, Cynomolgus (HEK293, His) Retinol-Binding Protein 4; Plasma Retinol-Binding Protein; PRBP; RBP; RBP4	Cynomolgus	HEK293
	RBP4 Protein, a vital retinol transporter in blood plasma, mediates the transfer from liver stores to peripheral tissues. It also enhances retinol transport by interacting with TTR. RBP4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived RBP4 protein, expressed by HEK293 , with C-His labeled tag.

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Host:	Mouse (3)
Reactivity:	Human (3)
Application:	IHC-P (2) IF-Tissue (2) IHC-F (2) WB (2) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85634

	RBP4 Antibody (YA5326) OTTHUMP00000020114; OTTHUMP00000020115; OTTHUMP00000020116; Plasma Retinol Binding Protein 4; Plasma Retinol-Binding Protein; Plasma Retinol-Binding Protein; 1-176; PRBP; PRO2222; RBP; RBP4; RDCCAS; RET4_HUMAN; Retinol Binding Protein 4; Retinol Binding Protein 4 interstitial; Retinol Binding Protein 4 plasma.	ELISA	Human
	RBP4 Antibody (YA5326) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to RBP4.

HY-P85349

	RBP4 Antibody (YA5041) RBP4; Retinol-Binding Protein 4; Plasma Retinol-Binding Protein; PRBP; RBP	WB, IHC-P, IHC-F, IF-Tissue	Human
	RBP4 Antibody (YA5041) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to RBP4.

HY-P85349A

	RBP4 Antibody (YA5041)(PBS only) RBP4; Retinol-Binding Protein 4; Plasma Retinol-Binding Protein; PRBP; RBP	WB, IHC-P, IHC-F, IF-Tissue	Human
	RBP4 Antibody (YA5041) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to RBP4.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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