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RBP4 inhibitor 1 (compound 43b) is a potent and orally active retinol-binding protein 4 (RBP4) inhibitor with IC50s of 28 nM and 110 nM for human and mouse RBP4. RBP4 inhibitor 1 has a potent and long-lasting blood RBP4-level-reducing effect in mice.

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RBP4 inhibitor 1 Chemical Structure

RBP4 inhibitor 1 Chemical Structure

CAS No. : 1198180-03-8

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5 mg USD 240 In-stock
10 mg USD 380 In-stock
25 mg USD 760 In-stock
50 mg USD 1220 In-stock
100 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

RBP4 inhibitor 1 (compound 43b) is a potent and orally active retinol-binding protein 4 (RBP4) inhibitor with IC50s of 28 nM and 110 nM for human and mouse RBP4. RBP4 inhibitor 1 has a potent and long-lasting blood RBP4-level-reducing effect in mice[1].

IC50 & Target

IC50: 28 nM (human RBP4) and 110 nM (mouse RBP4)[1]

Molecular Weight

357.25

Formula

C14H13F6NO3

CAS No.
Appearance

Solid

SMILES

O=C(O)CO[C@@H]1CN(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (699.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7992 mL 13.9958 mL 27.9916 mL
5 mM 0.5598 mL 2.7992 mL 5.5983 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7992 mL 13.9958 mL 27.9916 mL 69.9790 mL
5 mM 0.5598 mL 2.7992 mL 5.5983 mL 13.9958 mL
10 mM 0.2799 mL 1.3996 mL 2.7992 mL 6.9979 mL
15 mM 0.1866 mL 0.9331 mL 1.8661 mL 4.6653 mL
20 mM 0.1400 mL 0.6998 mL 1.3996 mL 3.4990 mL
25 mM 0.1120 mL 0.5598 mL 1.1197 mL 2.7992 mL
30 mM 0.0933 mL 0.4665 mL 0.9331 mL 2.3326 mL
40 mM 0.0700 mL 0.3499 mL 0.6998 mL 1.7495 mL
50 mM 0.0560 mL 0.2799 mL 0.5598 mL 1.3996 mL
60 mM 0.0467 mL 0.2333 mL 0.4665 mL 1.1663 mL
80 mM 0.0350 mL 0.1749 mL 0.3499 mL 0.8747 mL
100 mM 0.0280 mL 0.1400 mL 0.2799 mL 0.6998 mL
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RBP4 inhibitor 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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RBP4 inhibitor 1
Cat. No.:
HY-143793
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