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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
SREBP2
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "SREBP2" in MCE Product Catalog:
57
57 Publications Verification
Synonyms: 125B11
Target:
Research Areas:
Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice [2].
57
57 Publications Verification
Synonyms: 125B11 hydrobromide
Target:
Research Areas:
Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice [2].
6
Research Areas:
Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis (Ferroptosis), viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis [2] .
6
6 Cited Publications
1
1 Cited Publications
Cat. No.: HY-W510159
CAS No.: 56005-10-8
Target:
1
1 Cited Publications
Cat. No.: HY-113308S1
CAS No.: 2410279-96-6
1
1 Cited Publications
Cat. No.: HY-N12124
CAS No.: 1011244-19-1
Synonyms: Monascinol
Cat. No.: HY-RS13758
Target:
Research Areas:
SREBF2 Human Pre-designed siRNA Set A contains three designed siRNAs for SREBF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-113308AR
CAS No.: 6042-32-6
Cat. No.: HY-113308AS1
CAS No.: 1265476-97-8
Cat. No.: HY-N10702
Target:
Cat. No.: HY-119831
CAS No.: 71294-60-5
Target:
NF-κB CDK PPAR Akt mTOR LXR Reactive Oxygen Species (ROS) Apoptosis Wnt Interleukin Related p38 MAPK ERK JNK
Research Areas:
Rohitukine is an orally active CDK9/T1 inhibitor with an IC50 of 0.3 μM. Rohitukine blocks ATP binding sites of CDK2/A and CDK9/T1, suppresses PPARγ, AKT, mTOR, C/EBPα, SREBP-2, and NF-κB signaling, and increases hepatic LXRα expression. Rohitukine induces S-phase cell cycle arrest, ROS generation, apoptosis, and exhibits anti-inflammatory activity. Rohitukine can be used for the research of leukemia, pancreatic cancer, prostate cancer, breast cancer, CNS cancer, ovarian cancer, lung cancer, dyslipidemia, inflammatory diseases, inflammatory bowel disease, and arthritis [2] .
Cat. No.: HY-113308AS2
Cat. No.: HY-113308S
CAS No.: 1265681-64-8
Cat. No.: HY-RS28463
Target:
Research Areas:
Srebf2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Srebf2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21946
Target:
Research Areas:
Srebf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Srebf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-14452R
CAS No.: 125256-00-0
Research Areas:
Fatostatin (Standard) is the analytical standard of Fatostatin (HY-14452). This product is intended for research and analytical applications. Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice [2].
Cat. No.: HY-N20666
CAS No.: 120962-03-0
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
