10262-69-8
10262-69-8
Chemical Structure
Maprotiline
- CAS No.: 10262-69-8
- Formula:C20H23N
- Molecular Weight:277.40
IUPAC Name: 3-(9,10-ethanoanthracen-9(10H)-yl)-N-methylpropan-1-amine
InChIKey: QSLMDECMDJKHMQ-UHFFFAOYSA-N
SMILES: CNCCCC12C3=C(C=CC=C3)C(CC2)C4=CC=CC=C14
Biological Activity: Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1[1][2].
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Maprotiline | Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1. | |||||||||||||||||||||
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References
- [1]. Zheng C, et al. Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1. Front Pharmacol. 2021 May 20. 12:689767. [Content Brief]
- [2]. Gunduz O, et al. Analysis of the anti-allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re-uptake inhibitor in nerve injury-induced neuropathic mice. Eur J Pain. 2016 Mar. 20(3):465-71.
