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Sgc8c-VcMMAE

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Sgc8c-VcMMAE" in MCE Product Catalog:

Sgc8c-M
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Sgc8c-M
Cat. No.: HY-177571
Synonyms: Sgc8c-VcMMAE
Sgc8c-M is a PTK7-targeted aptamer-drug conjugate (ApDC). Sgc8c-M is composed of the classic PTK7-specific aptamer Sgc8c, a cathepsin B (CTSB)-cleavable valine-citrulline (VC)-based linker, and the potent antimitotic agent Monomethyl auristatin E (MMAE) (HY-15162) as the payload. Sgc8c-M inhibits the growth of PTK7-overexpressing cancer cells. Sgc8c-M can be used for the study of PTK7-expressing advanced solid tumors .
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