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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Sirtuin-3
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Sirtuin-3" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (Kd=2.756 μM), antagonizes Isoproterenol/ISO (HY-B0468)-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-β/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure .
Cat. No.: HY-173572
CAS No.: 433953-86-7
Research Areas:
SKLB-11A is a selective, orally active and allosteric SIRT3 (sirtuin 3) agonist with a Kd value of 4.7 μM. SKLB-11A is highly selective for other members of the SIRT family. SKLB-11A activates autophagy-related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin (HY-15142A)-induced cardiotoxicity and myocardial ischemia/reperfusion models .
Cat. No.: HY-N2673
CAS No.: 41442-57-3
Synonyms: 5-n-Heptadecylresorcinol; AR-C17
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Target:
Cat. No.: HY-N2673R
CAS No.: 41442-57-3
Synonyms: 5-n-Heptadecylresorcinol (Standard); AR-C17 (Standard)
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Target:
Cat. No.: HY-P701609
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SIRT3; NAD-dependent protein deacetylase Sirtuin-3; mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3
Cat. No.: HY-P701610
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SIRT3; NAD-dependent protein deacetylase Sirtuin-3; mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3
Cat. No.: HY-P702774
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SIRT3; NAD-dependent protein deacetylase Sirtuin-3; mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
