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Synthetic

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1543

Inhibitors & Agonists

20

Screening Libraries

52

Fluorescent Dye

113

Biochemical Assay Reagents

246

Peptides

3

Inhibitory Antibodies

104

Natural
Products

156

Isotope-Labeled Compounds

23

Click Chemistry

43

Oligonucleotides

3

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N4115
    Syrosingopine
    10+ Cited Publications

    Su 3118

    		 Monocarboxylate Transporter Cardiovascular Disease Cancer
    Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine .
    Syrosingopine
  • HY-P3375
    Mazdutide

    IBI-362; LY-3305677; OXM-3

    		 GCGR GLP Receptor Metabolic Disease
    Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D) .
    Mazdutide
  • HY-D1373
    HBC
    3 Publications Verification

    HBC 530

    		 Fluorescent Dye Others
    HBC (HBC 530) is a GFP fluorophore-like synthetic dye, with a structurally rigid electron acceptor and a strong electron donor. HBC has a low fluorescence background, and when combined with Pepper (RNA aptamer), HBC forms a tight complex and activates and emits bright fluorescence (Kd of ~3.5 nM). HBC emission peaks vary in different complexes and covers the spectrum from cyan to red. HBC can be used in the live cell imaging of RNA (Em/Ex = 530/485 nm) .
    HBC
  • HY-B1278B
    (±)-α-Tocopherol acetate

    (±)-Vitamin E acetate

    		 Environmental Pollutants Biochemical Assay Reagents Infection
    (±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases .
    (±)-α-Tocopherol acetate
  • HY-134581A
    Enpatoran hydrochloride
    15+ Cited Publications

    M5049 hydrochloride

    		 Toll-like Receptor (TLR) Inflammation/Immunology
    Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride is inactive against TLR3, TLR4 and TLR9. Enpatoran hydrochloride can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran hydrochloride exhibits excellent pharmacokinetic properties in vivo. Enpatoran hydrochloride can be used for both innate and adaptive autoimmunity blocking research .
    Enpatoran hydrochloride
  • HY-17405
    Alarelin Acetate
    1 Publications Verification

    Alarelin

    		 GnRH Receptor Endocrinology
    Alarelin acetate is a synthetic GnRH agonist.
    Alarelin Acetate
  • HY-P0290
    GRGDSP
    5 Publications Verification

    		 Integrin Cancer
    GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.
    GRGDSP
  • HY-B1662
    Hexestrol
    2 Publications Verification

    		 Estrogen Receptor/ERR Endocrinology
    Hexestrol is a nonsteroidal synthetic estrogen, with a Ki of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle .
    Hexestrol
  • HY-17564
    2'-Deoxycytidine hydrochloride
    Maximum Cited Publications
    9 Publications Verification

    2'-Deoxycytidine monohydrochloride; Deoxycytidine hydrochloride; NSC 83251

    		 Endogenous Metabolite Nucleoside Antimetabolite/Analog Cancer
    2'-Deoxycytidine hydrochloride is an orally effective nucleic acid biosynthesis enzyme inhibitor. 2'-Deoxycytidine hydrochloride competes with nucleic acid biosynthesis enzymes and nucleoside transporters, thereby reducing the toxicity of cytarabine. 2'-Deoxycytidine (hydrochloride) can be used in the research of L1210 lymphoblastic leukemia .
    2'-Deoxycytidine hydrochloride
  • HY-W002603
    Benzyl piperazine-1-carboxylate

    		Biochemical Assay Reagents Drug Intermediate Neurological Disease
    Benzyl piperazine-1-carboxylate is a synthetic intermediate that can be used in the research of melanocortin-4 (MC4) receptor antagonists .
    Benzyl piperazine-1-carboxylate
  • HY-P3375A
    Mazdutide TFA

    IBI-362 TFA; LY-3305677 TFA; OXM-3 TFA

    		 GCGR GLP Receptor Metabolic Disease
    Mazdutide (IBI-362; LY-3305677) TFA is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide TFA binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide TFA is used in studies of obesity and type 2 diabetes (T2D) .
    Mazdutide TFA
  • HY-125553
    Hexapeptide-10

    Serilesine

    		 Amino Acid Derivatives Others
    Hexapeptide-10 (Serilesine) is a synthetic hexapeptide. Hexapeptide-10 promotes wound healing and tissue remodeling. Hexapeptide-10 is applicable in cosmetic research .
    Hexapeptide-10
  • HY-75813
    2-Aminonicotinaldehyde

    		Biochemical Assay Reagents Akt 5-HT Receptor Neurological Disease Cancer
    2-Aminonicotinaldehyde is a synthetic intermediate. 2-Aminonicotinaldehyde can be used for the synthesis of 5-HT3 receptor antagonists, AKT inhibitors, and other compounds. 2-Aminonicotinaldehyde is applicable to research on depression and cancers (including hepatocellular carcinoma) .
    2-Aminonicotinaldehyde
  • HY-17578
    Pneumocandin B0

    L-688786

    		 Drug Intermediate Infection
    Pneumocandin B0 (L-688786) is the precursor of the synthetic antifungal agent Cancidas (Caspofungin acetate) (HY-17006). Pneumocandin B0 can be isolated from fungus Glarea lozoyensis .
    Pneumocandin B0
  • HY-112205
    RR-11a
    3 Publications Verification

    		 Legumain Cancer
    RR-11a is a synthetic enzyme inhibitor of Legumain (IC50=31-55 nM). RR-11a can be used for the research of cancer and acute myocardial infarction (AMI) .
    RR-11a
  • HY-153361
    YD23

    		PROTACs Epigenetic Reader Domain Inflammation/Immunology Cancer
    YD23 is a selective SMARCA2 PROTAC degrader with DC50 values of 64 nM and 297 nM in H1792 cells and H1975 cells. YD23 induces degradation of SMARCA2, which is synthetic lethal to SMARCA4. YD23 reduces chromatin accessibility only in SMARCA4 deficient cells, including cell cycle and cell growth regulatory genes. YD23 selectively inhibits growth of SMARCA4 mutant lung cancer cells. YD23 has potent tumor growth inhibitory activity in SMARCA4-mutant xenografts. YD23 can be used for the study of non-small cell lung cancer (NSCLC) .
    YD23
  • HY-A0104K
    HPMC (Type II,Viscosity:3mPa.s)

    Hypromellose (Type II,Viscosity:3mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:3mPa.s); Celacol HPM 5000 (Type II,Viscosity:3mPa.s)

    		 Environmental Pollutants Biochemical Assay Reagents Others
    HPMC (Type II, Viscosity: 3 mPa.s) is a nonionic polymer prepared via synthetic modification of cellulose. As a hydrophilic matrix material, HPMC prolongs drug release through non-Fickian diffusion, which includes the diffusion of drugs in the hydrated matrix and the polymer relaxation process .
    HPMC (Type II,Viscosity:3mPa.s)
  • HY-P1626
    Acetyl tetrapeptide-15

    		Opioid Receptor Neurological Disease
    Acetyl tetrapeptide-15 is a synthetic peptide. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway. Acetyl tetrapeptide-15 is used in the cosmetics for sensitive skin .
    Acetyl tetrapeptide-15
  • HY-W016618
    Ethyl phenylglyoxylate

    Ethyl benzoylformate; Phenylglyoxylic acid ethyl ester

    		 Drug Intermediate Biochemical Assay Reagents Carboxylesterase (CES) Others
    Ethyl phenylglyoxylate (Ethyl benzoylformate), the ethyl ester of phenylglyoxylic acid, is used as a synthetic reagent. Ethyl phenylglyoxylate is also a poor substrate but a potent inhibitor of chicken liver carboxylesterase. Additionally, Ethyl phenylglyoxylate exhibits photoreactivity, where its excited triplet carbonyl can initiate intermolecular hydrogen abstraction, radical coupling and cross-linking reactions .
    Ethyl phenylglyoxylate
  • HY-P1701
    Morphiceptin

    		Opioid Receptor Cardiovascular Disease Neurological Disease
    Morphiceptin is a potent and specific agonist for morphine (μ) receptors. Morphiceptin, as a synthetic peptide, is the amide of a fragment of the milk protein β-casein. Morphiceptin has morphinelike activities and is highly specific for morphine (μ) receptors but not for Enkephalin receptors .
    Morphiceptin
  • HY-128753
    D-Lyxose

    		Endogenous Metabolite Drug Intermediate Metabolic Disease
    D-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose with significant potential for pharmaceutical synthesis. D-Lyxose serves as a starting material for antitumor agents (such as α-galactosylceramide-based immunostimulants). D-Lyxose acts as a precursor for L-nucleoside analogs used in the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars (such as L-ribose) .
    D-Lyxose
  • HY-W008321
    6-Bromo-3,4-dihydro-1(2H)-naphthalenone

    		Biochemical Assay Reagents Metabolic Disease
    6-Bromo-3,4-dihydro-1 (2H)-naphthalenone is a synthetic intermediate. 6-Bromo-3,4-dihydro-1 (2H)-naphthalenone can be used for the synthesis of 2-Benzyl-6-bromo-3,4-dihydro-1 (2H)-naphthalenone. 6-Bromo-3,4-dihydro-1 (2H)-naphthalenone can be applied to the development of hypoglycemic agents .
    6-Bromo-3,4-dihydro-1(2H)-naphthalenone
  • HY-119506
    KL044
    1 Publications Verification

    		 Cryptochrome Metabolic Disease
    KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity .
    KL044
  • HY-U00089
    Hydrocortisone cypionate
    1 Publications Verification

    		 Glucocorticoid Receptor Inflammation/Immunology Endocrinology
    Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.
    Hydrocortisone cypionate
  • HY-34590
    3-Amino-2,6-piperidinedione

    		Drug Intermediate Cancer
    3-Amino-2,6-piperidinedione is a synthetic intermediate that has been used to design antitumor compounds .
    3-Amino-2,6-piperidinedione
  • HY-117444
    ONO-9780307

    		LPL Receptor Cancer
    ONO-9780307 is a specific synthetic LPA1 (lysophosphatidic acid receptor 1) antagonist with an IC50 value of 2.7 nM .
    ONO-9780307
  • HY-W250152
    Polycytidylic acid potassium

    		Biochemical Assay Reagents Inflammation/Immunology
    Polycytidylic acid potassium is an immunostimulant and synthetic double-stranded RNA. Polycytidylic acid potassium can be used experimentally to model viral infections in vivo. Polycytidylic acid potassium is a common tool in immune system research .
    Polycytidylic acid potassium
  • HY-161752
    Antibacterial agent 224

    		Bacterial Infection
    Antibacterial agent 224 is a potent and selective synthetic hydrazone inhibitor against the Salmonella PhoP/PhoQ system .
    Antibacterial agent 224
  • HY-21629
    N-Boc-4-piperidinemethanol

    		Cholinesterase (ChE) Drug Intermediate Others
    N-Boc-4-piperidinemethanol (Compound 4) is a synthetic intermediate. N-Boc-4-piperidinemethanol can be used for the preparation of Acetylcholinesterase inhibitors .
    N-Boc-4-piperidinemethanol
  • HY-137709A
    2'2'-cGAMP disodium
    1 Publications Verification

    		 STING IFNAR Endogenous Metabolite Metabolic Disease
    2'2'-cGAMP disodium, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP disodium binds weaker binding to STING than 2'3'-cGAMP (HY-100564) but stronger than other CDNs .
    2'2'-cGAMP disodium
  • HY-167545
    1-Palmitoyl-2-oleoylphosphatidylethanolamine

    POPE

    		 Liposome Biochemical Assay Reagents Others
    1-Palmitoyl-2-oleoylphosphatidylethanolamine (POPE) is a PE-based synthetic phospholipid that can intercalate with other amphiphilic molecules to form stable bilayers at physiological pH. 1-Palmitoyl-2-oleoylphosphatidylethanolamine can be used in drug delivery research .
    1-Palmitoyl-2-oleoylphosphatidylethanolamine
  • HY-B1278BR
    (±)-α-Tocopherol acetate (Standard)

    (±)-Vitamin E acetate (Standard)

    		 Biochemical Assay Reagents Reference Standards Infection
    (±)-α-Tocopherol acetate (Standard) is the analytical standard of (±)-α-Tocopherol acetate. This product is intended for research and analytical applications. (±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases .
    (±)-α-Tocopherol acetate (Standard)
  • HY-40040
    (S)-1-Boc-3-methylpiperazine

    		Drug Intermediate Infection
    (S)-1-Boc-3-methylpiperazine is a synthetic intermediate for indole-piperazine hybrid antimicrobial agent preparation. (S)-1-Boc-3-methylpiperazine can be used for research on bacterial infection and fungal infection .
    (S)-1-Boc-3-methylpiperazine
  • HY-B1182
    Chromocarb

    Chromone-2-carboxylic acid

    		 Drug Derivative Cardiovascular Disease
    Chromocarb is a synthetic vascular protector.
    Chromocarb
  • HY-169784
    PPI-1040

    		Drug Derivative Metabolic Disease
    PPI-1040 is an orally bioavailable vinyl ether synthetic plasmalogen. PPI-1040 acts as a precursor of plasmalogen. PPI-1040 increases plasmalogen levels in plasmalogen-deficient mice and normalizes hyperactive behaviors in these mice. In wild-type mice, PPI-1040 retains the sn-1 vinyl ether group and sn-3 phosphoethanolamine group, and is converted into endogenous ethanolamine plasmalogen. PPI-1040 can be used in studies related to rhizomelic chondrodysplasia punctata .
    PPI-1040
  • HY-60346
    2-Pyrimidinecarboxylic acid

    2-Carboxy-Pyrimidine

    		 Drug Intermediate Infection
    2-Pyrimidinecarboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis .
    2-Pyrimidinecarboxylic acid
  • HY-145860
    PHGDH-IN-2

    		Phosphoglycerate Dehydrogenase (PHGDH) Cancer
    PHGDH-IN-2 is a potent and NAD + competitive PHGDH inhibitor with an IC50 of 5.2 µM. PHGDH-IN-2 inhibits the serine synthetic pathway in MDA-MB-468 cells. PHGDH-IN-2 inhibits the growth of PHGDH-dependent cancer cells .
    PHGDH-IN-2
  • HY-151661
    N3-L-Val-OH (CHA)

    L-azidovaline (CHA)

    		 ADC Linker Others
    N3-L-Val-OH (CHA) is a click chemistry containing an azide group, a valine derivative. N3-L-Val-OH (CHA) can also be used as a synthetic intermediate for Valaciclovir (Valacyclovir) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    N3-L-Val-OH (CHA)
  • HY-P10462
    SAP15

    Synthetic anti-inflammatory peptide 15

    		 HDAC NF-κB Inflammation/Immunology
    SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation in LPS (HY-D1056)-induced macrophages. SAP15 increases the expression of aggrecan and type II collagen and decreases the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials .
    SAP15
  • HY-13952
    TP-808

    		Drug Intermediate Bacterial Others
    TP-808 is a key enone intermediate for the discovery and manufacture of Tetracycline (HY-A0107) analogs and synthetic tetracyclines including eravacycline .
    TP-808
  • HY-137709
    2'2'-cGAMP

    		STING IFNAR Endogenous Metabolite Metabolic Disease
    2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP binds weaker binding to STING than 2'3'-cGAMP (HY-100564) but stronger than other CDNs .
    2'2'-cGAMP
  • HY-P5309
    IgA1 Peptide GN5

    		Biochemical Assay Reagents Inflammation/Immunology
    IgA1 Peptide GN5 is a synthetic glycopeptide and can be used for detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients .
    IgA1 Peptide GN5
  • HY-114671
    Taprostene

    CG-4203

    		 Prostaglandin Receptor Cardiovascular Disease
    Taprostene (CG-4203) is a synthetic, chemically stable analogue of Prostacyclin (PGI2). Taprostene exhibits endothelium and myocardial protecting actions after acute myocardial ischemia and reperfusion in cats. Taprostene enhances cytoprotective actions, while minimizing unwanted hemodynamic effects .
    Taprostene
  • HY-43001
    (−)-G-Lactone

    		Drug Intermediate Others
    (−)-G-Lactone is a synthetic intermediate useful for prostaglandins synthesis .
    (−)-G-Lactone
  • HY-P10462A
    SAP15 acetate

    Synthetic anti-inflammatory peptide 15 acetate

    		 HDAC NF-κB Inflammation/Immunology
    SAP15 (Synthetic anti-inflammatory peptide 15) acetate is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 acetate has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 acetate inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. SAP15 acetate inhibits HDAC5 and NF-κB p65 phosphorylation in LPS (HY-D1056)-induced macrophages. SAP15 acetate increases the expression of aggrecan and type II collagen and decreases the expression of osteocalcin in LPS-induced chondrocytes. SAP15 acetate can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials .
    SAP15 acetate
  • HY-164652
    m-BBIG dihydrochloride

    		Biochemical Assay Reagents Others
    m-BBIG dihydrochloride is a member of Bis-iminoguanidine (BIG) family and can be utilized in synthetic chemistry .
    m-BBIG dihydrochloride
  • HY-41004
    3-Isoquinolinecarboxylic acid

    		Drug Intermediate Cancer
    3-Isoquinolinecarboxylic acid (compound 2) is a synthetic intermediate that has been used to design antitumor compounds .
    3-Isoquinolinecarboxylic acid
  • HY-N8495
    4'-Hydroxyflavanone

    		Others Metabolic Disease
    4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research .
    4'-Hydroxyflavanone
  • HY-P5309A
    IgA1 Peptide GN5 TFA

    		Biochemical Assay Reagents Inflammation/Immunology
    IgA1 Peptide GN5 (TFA) is a synthetic glycopeptide and can be used for detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients .
    IgA1 Peptide GN5 TFA
  • HY-N4115R
    Syrosingopine (Standard)

    Su 3118 (Standard)

    		 Reference Standards Monocarboxylate Transporter Cardiovascular Disease Cancer
    Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine .
    Syrosingopine (Standard)

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