347174-05-4
347174-05-4
Chemical Structure
Ferrostatin-1
Synonym(s): Fer-1
- CAS No.: 347174-05-4
- Formula:C15H22N2O2
- Molecular Weight:262.35
IUPAC Name: ethyl 3-amino-4-(cyclohexylamino)benzoate
InChIKey: UJHBVMHOBZBWMX-UHFFFAOYSA-N
SMILES: O=C(OCC)C1=CC=C(NC2CCCCC2)C(N)=C1
Biological Activity: Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ferrostatin-1 | 99.71% | Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity. | ||||||||||||||||||||
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Ferrostatin-1 (Standard) | ≥98% | Ferrostatin-1 (Standard) is the analytical standard of Ferrostatin-1 (HY-100579). This product is intended for research and analytical applications. Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity. | ||||||||||||||||||||
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References
- [1]. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060-1072. [Content Brief]
- [2]. Skouta R, Dixon SJ, Wang J, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014;136(12):4551-4556. [Content Brief]
- [3]. Horwath MC, et al. Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem. 2017;18(20):2069-2078. [Content Brief]
