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  4. DCPD

DCPD is an amine substance with both embryotoxicity and teratogenicity, and its total effect ED50 is 0.6 μmol per egg. DCPD induces early and late embryonic death, and causes multiple embryonic malformations including microcephaly, hypoplastic optic cup, eyelid and corneal defects. DCPD can serve as a calcium phosphate additive for biomimetic α-tricalcium phosphate bone cement, which inhibits the transformation of α-tricalcium phosphate into calcium-deficient hydroxyapatite, blocks the release of Gelatins (HY-Y1365), and effectively prolongs the setting time of bone cement. DCPD is applicable to studies related to embryonic malformations.\n

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DCPD

DCPD Chemical Structure

CAS No. : 4175-38-6

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DCPD Related Antibodies

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Description

DCPD is an amine substance with both embryotoxicity and teratogenicity, and its total effect ED50 is 0.6 μmol per egg. DCPD induces early and late embryonic death, and causes multiple embryonic malformations including microcephaly, hypoplastic optic cup, eyelid and corneal defects. DCPD can serve as a calcium phosphate additive for biomimetic α-tricalcium phosphate bone cement, which inhibits the transformation of α-tricalcium phosphate into calcium-deficient hydroxyapatite, blocks the release of Gelatins (HY-Y1365), and effectively prolongs the setting time of bone cement. DCPD is applicable to studies related to embryonic malformations[1][2].\n
In Vitro

DCPD prolongs the initial and final setting times of gelatin-α-TCP bone cement, and 15 wt.% DCPD completely inhibits setting; it reduces the long-term conversion rate of α-TCP to CDHA in gelatin-α-TCP bone cement and prevents the release of gelatin from gelatin-α-TCP bone cement during immersion in physiological solution[2].
DCPD dissolves rapidly in gelatin-α-TCP bone cements immersed in physiological solutions, and the dissolution rate decreases with the increase of initial DCPD content[2].
DCPD improves the mechanical properties of gelatin-α-TCP bone cement; it alters the morphological development during the curing process of gelatin-α-TCP bone cement, forming a denser surface and smaller crystals at DCPD concentrations of 2.5 wt.% and 5 wt.%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DCPD Related Antibodies
In Vivo

DCPD (0.36-2.9 μmol per egg; local injection onto inner shell membrane over embryo; single dose) exhibits embryotoxic and teratogenic activity in 3-day White Leghorn chicken embryos, with an estimated total effect ED50 of 0.6 μmol per egg, primarily inducing small head malformations at sublethal doses[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: White Leghorn (3-day/72-76 h embryos)[1]
Dosage: 0.36 μmol per egg; 0.73 μmol per egg; 1.5 μmol per egg; 2.9 μmol per egg
Administration: local injection onto inner shell membrane over embryo; single dose
Result: Triggered 3% early deaths, 3% late malformed deaths, 23% malformed survivors and 30% affected embryos at 0.36 μmol per egg.
Triggered 3% early deaths, 57% malformed survivors and 60% affected embryos at 0.73 μmol per egg.
Triggered 83% malformed survivors and 83% affected embryos at 1.5 μmol per egg.
Triggered 10% early deaths, 3% late malformed deaths, 43% malformed survivors and 57% affected embryos at 2.9 μmol per egg.
Exhibited an overall ED50 (deaths plus malformations) of 0.6 μmol per egg.
Induced prevalent small head malformations (96%) plus minor ocular, body wall, skeletal, wing and oedema lesions among 51 malformed embryos with 70 recorded defects.
Molecular Weight

272.43

Formula

C18H28N2
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

C1(NC2CCCCC2)=CC=C(NC3CCCCC3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (73.41 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6707 mL 18.3533 mL 36.7067 mL
5 mM 0.7341 mL 3.6707 mL 7.3413 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 95.0%

SDS (252 KB)

COA (244 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6707 mL 18.3533 mL 36.7067 mL 91.7667 mL
5 mM 0.7341 mL 3.6707 mL 7.3413 mL 18.3533 mL
10 mM 0.3671 mL 1.8353 mL 3.6707 mL 9.1767 mL
15 mM 0.2447 mL 1.2236 mL 2.4471 mL 6.1178 mL
20 mM 0.1835 mL 0.9177 mL 1.8353 mL 4.5883 mL
25 mM 0.1468 mL 0.7341 mL 1.4683 mL 3.6707 mL
30 mM 0.1224 mL 0.6118 mL 1.2236 mL 3.0589 mL
40 mM 0.0918 mL 0.4588 mL 0.9177 mL 2.2942 mL
50 mM 0.0734 mL 0.3671 mL 0.7341 mL 1.8353 mL
60 mM 0.0612 mL 0.3059 mL 0.6118 mL 1.5294 mL
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DCPD Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCPD4175-38-6Biochemical Assay ReagentscoelomWhite Leghorn chicken embryosembryotoxicantcornea defectslymph blebsgelatin-α-TCP bone cementsα-tricalcium phosphatecalcium deficient hydroxyapatiteteratogenembryonic malformationsInhibitorinhibitorinhibit

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