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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
TG-2-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "TG-2-IN-1" in MCE Product Catalog:
2
2 Cited Publications
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Research Areas:
TG-2-IN-1 (Compound D003) is a transglutaminase-2 (TGM-2) inhibitor. TG-2-IN-1 can be used for the research of myopia .
TG2-179-1 is a potent BAP1 inhibitor. TG2-179-1 inhibits the domain-containing deubiquitinase (DUB) activity of BAP1 by covalently binding to its active site. TG2-179-1 exerts cytotoxic activity, leading to defective replication and increased apoptosis. TG2-179-1 has the potential for colon cancer research .
Cat. No.: HY-155643
CAS No.: 3033465-55-0
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Research Areas:
PROTAC TG2 degrader-1 is a tissue transglutaminase (TG2) PROTAC degrader with a Kd of 68.9 μM. PROTAC TG2 degrader-1 recruits the VHL E3 ubiquitin ligase to the fibronectin-binding site of TG2, forms a ternary complex, and induces proteasome-dependent degradation of TG2. PROTAC TG2 degrader-1 inhibits ovarian cancer cell migration and adhesion to fibronectin, without producing a significant inhibitory effect on cell proliferation. PROTAC TG2 degrader-1 can be used in related research on ovarian cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
