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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
TGR5 activator
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "TGR5 activator" in MCE Product Catalog:
30
30 Publications Verification
Synonyms: Ursodeoxycholate; Ursodiol; UDCA
30
30 Publications Verification
Synonyms: Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium
6
Research Areas:
Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis (Ferroptosis), viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .
6
6 Cited Publications
4
4 Cited Publications
Cat. No.: HY-B1899A
CAS No.: 110026-03-4
Synonyms: Taurodeoxycholate sodium hydrate
2
Research Areas:
Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes .
1
1 Cited Publications
Cat. No.: HY-N0593S
CAS No.: 112076-61-6
1
1 Cited Publications
Cat. No.: HY-N0910
CAS No.: 155683-00-4
Cat. No.: HY-120565
CAS No.: 1594041-84-5
Research Areas:
WB403 is an orally active TGR5 activator with an EC50 of 5.5 μM against human TGR5. WB403 activates TGR5 to stimulate downstream signaling pathways, promote GLP-1 secretion, improve glucose tolerance in mice with type 2 diabetes, and reduce levels of fasting blood glucose, postprandial blood glucose and HbA1c. WB403 increases pancreatic β-cell mass and restores the distribution of α-cells and β-cells in islets. WB403 is applicable to the research of type 2 diabetes .
Synonyms: Ursodeoxycholate-d4; Ursodiol-d4; UDCA-d4
Cat. No.: HY-N3266
CAS No.: 99353-00-1
Synonyms: Ursodeoxycholate (Standard); Ursodiol (Standard); UDCA (Standard)
Cat. No.: HY-N0593S1
CAS No.: 52840-14-9
Cat. No.: HY-N0593S3
CAS No.: 52886-37-0
Synonyms: Cholanoic Acid-13C; Desoxycholic acid-13C
Cat. No.: HY-113308S1
CAS No.: 2410279-96-6
Cat. No.: HY-N0593S2
CAS No.: 2483832-09-1
Synonyms: Cholanoic acid-d6; Desoxycholic acid-d6
Cat. No.: HY-113308AR
CAS No.: 6042-32-6
Cat. No.: HY-13771S1
CAS No.: 63296-46-8
Synonyms: Ursodeoxycholate-13C; Ursodiol-13C; UDCA-13C
Cat. No.: HY-113308AS1
CAS No.: 1265476-97-8
Cat. No.: HY-W089835R
CAS No.: 207737-97-1
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
