1594041-84-5
Chemical Structure
WB403
- CAS No.: 1594041-84-5
- Formula:C19H19BrN2OS
- Molecular Weight:403.34
IUPAC Name: 5-(((4-bromobenzyl)oxy)methyl)-2-(2-ethylpyridin-4-yl)-4-methylthiazole
InChIKey: NYKBJEUCSJOODJ-UHFFFAOYSA-N
SMILES: CCC1=NC=CC(C2=NC(C)=C(S2)COCC3=CC=C(C=C3)Br)=C1
Biological Activity: WB403 is an orally active TGR5 activator with an EC50 of 5.5 μM against human TGR5. WB403 activates TGR5 to stimulate downstream signaling pathways, promote GLP-1 secretion, improve glucose tolerance in mice with type 2 diabetes, and reduce levels of fasting blood glucose, postprandial blood glucose and HbA1c. WB403 increases pancreatic β-cell mass and restores the distribution of α-cells and β-cells in islets. WB403 is applicable to the research of type 2 diabetes[1].
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WB403 | 99.16% | WB403 is an orally active TGR5 activator with an EC50 of 5.5 μM against human TGR5. WB403 activates TGR5 to stimulate downstream signaling pathways, promote GLP-1 secretion, improve glucose tolerance in mice with type 2 diabetes, and reduce levels of fasting blood glucose, postprandial blood glucose and HbA1c. WB403 increases pancreatic β-cell mass and restores the distribution of α-cells and β-cells in islets. WB403 is applicable to the research of type 2 diabetes. | ||||||||||||||||||||
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Keywords
