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Isoforms Recommended:	TRIM21 TRIM21

Results for "

TRIM21

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Drug Derivative (2) E1/E2/E3 Enzyme (5) E3 Ligase Ligand-Linker Conjugates (2) Epigenetic Reader Domain (2) HIF/HIF Prolyl-Hydroxylase (2) Interleukin Related (1) Ligands for E3 Ligase (1) Molecular Glues (6) PROTACs (3) Ras (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (11) Infection (1) Inflammation/Immunology (3) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-170430

HGC652	Molecular Glues E1/E2/E3 Enzyme	Cancer
HGC652 is a molecular glue degrader targeting *TRIM21* with a TRIM21-dependent nuclear membrane disruption effect. HGC652 binds to the PRY-SPRY domain of TRIM21 with high affinity (K_a=0.061 μM), mediates the interaction between TRIM21 and NUP98, and redirects E3 ligase activity. By triggering the polyubiquitination and proteasomal degradation of nucleoporins (such as NUP155 and GLE1), HGC652 disrupts nuclear membrane integrity, alters nuclear morphology, induces genomic instability, and thereby induces cancer cell death .

HY-119264

PRLX-93936	Molecular Glues Ras Apoptosis HIF/HIF Prolyl-Hydroxylase	Cancer
PRLX-93936 is a molecular Glues that binds to and reprograms the *TRIM21* ubiquitin ligase to degrade nuclear pore complexes. PRLX-93936 binds to *TRIM21, forms a ternary complex with TRIM21* and NUP98, and mediates the ubiquitination and proteasomal degradation of NUP98 and other nuclear pore complex proteins. PRLX-93936 induces the loss of short-lived cytoplasmic mRNA transcripts, triggers cancer cell apoptosis (Apoptosis), and inhibits the activated Ras pathway. PRLX-93936 inhibits HIF-1 under hypoxic conditions (IC₅₀ = 0.09 μM in cell-based reporter gene assay). PRLX-93936 suppresses tumor growth in mouse models and improves survival rates in mouse models of multiple myeloma. PRLX-93936 is applicable to research related to pancreatic cancer and multiple myeloma .

HY-169357

Acepromazine-1-piperazinepropanamine	E3 Ligase Ligand-Linker Conjugates	Cancer
Acepromazine-1-piperazinepropanamine (compound 10) is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugate) that incorporates a TRIM21 ligand and a linker. Acepromazine-1-piperazinepropanamine can be connected to the target protein ligand to form a PROTAC molecule, TrimTAC1 (HY-169355) .

HY-119264A

PRLX-93936 dihydrochloride	Molecular Glues Apoptosis Ras HIF/HIF Prolyl-Hydroxylase	Cancer
PRLX-93936 dihydrochloride is a molecular Glues that binds to and reprograms the *TRIM21* ubiquitin ligase to degrade nuclear pore complexes. PRLX-93936 dihydrochloride binds to *TRIM21, forms a ternary complex with TRIM21* and NUP98, and mediates the ubiquitination and proteasomal degradation of NUP98 and other nuclear pore complex proteins. PRLX-93936 dihydrochloride induces the loss of short-lived cytoplasmic mRNA transcripts, triggers cancer cell apoptosis (Apoptosis), and inhibits the activated Ras pathway. PRLX-93936 dihydrochloride inhibits HIF-1 under hypoxic conditions (IC₅₀ = 0.09 μM in cell-based reporter gene assay). PRLX-93936 dihydrochloride suppresses tumor growth in mouse models and improves survival rates in mouse models of multiple myeloma. PRLX-93936 dihydrochloride is applicable to research related to pancreatic cancer and multiple myeloma .

HY-169325

(S)-ACE-OH	Molecular Glues	Cancer
(S)-ACE-OH is a molecular glue with anticancer activity. (S)-ACE-OH promotes nucleoporin degradation and disruption of nucleocytoplasmic trafficking by inducing the interaction between E3 ubiquitin ligase *TRIM21* and nucleoporin NUP98 .

HY-RS15026

TRIM21 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRIM21 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM21 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRIM21 Human Pre-designed siRNA Set A TRIM21 Human Pre-designed siRNA Set A

HY-169357B

Acepromazine-1-piperazinepropanamine dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Acepromazine-1-piperazinepropanamine dihydrochloride (compound 10) is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugate) that incorporates a TRIM21 ligand and a linker. Acepromazine-1-piperazinepropanamine dihydrochloride can be connected to the target protein ligand to form a PROTAC molecule, TrimTAC1 (HY-169355) .

HY-RS16764

Trim21 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trim21 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trim21 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trim21 Mouse Pre-designed siRNA Set A Trim21 Mouse Pre-designed siRNA Set A

HY-169356

Acepromazine-OTs	Ligands for E3 Ligase	Cancer
Acepromazine-OTs is a *TRIM21* ligand used in the recruitment of the TRIM21 protein. Acepromazine-OTs can be connected to the target protein ligand through a linker to form a PROTAC molecule, TrimTAC1 (HY-169355) .

HY-RS23204

Trim21 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trim21 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trim21 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trim21 Rat Pre-designed siRNA Set A Trim21 Rat Pre-designed siRNA Set A

HY-175354

PROTAC BET Degrader-13	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BET Degrader-13 (Compound 34) is a TRIM21-based PROTAC (TRIMTAC) degrader targeting BET. PROTAC BET Degrader-13 significantly degrades PML-eGFP-BRD4 fusion protein with a near-complete loss of EGFP+ nuclear puncta with an EC₅₀ of 1.4 μM . Pink: BET ligand (HY-13030); Blue: E3 ligase ligand (HY-W1125585); Black: linker

HY-169355

TrimTAC1	PROTACs Epigenetic Reader Domain	Cancer
TrimTAC1 is a TRIM21-based PROTAC targeting BRD4. TrimTAC1 selectively degrads NUP98 ^FG-mEGFP-BRD4 ^BD2 nuclear condensates. TrimTAC1 does not degrade soluble mEGFP-BRD4 ^BD2 in A549 cells. (Pink: target protein ligand (+)-JQ-1 (HY-13030); Blue:E3 ligase ligand Acepromazine-OTs (HY-169356); Black: PROTAC linker (HY-W088456); E3 ligase ligand + linker: HY-169357) .

HY-185652

dTAG-TRIMTAC	PROTACs E1/E2/E3 Enzyme	Neurological Disease Inflammation/Immunology
dTAG-TRIMTAC is a PROTAC-like degrader targeting *TRIM21. dTAG-TRIMTAC forms a ternary complex with TRIM21* and target proteins to drive degradation of oligomeric/assembled substrates via TRIM21 clustering-based activation, with degradation dependent on endogenous TRIM21. dTAG-TRIMTAC can be used for the research of neurodegenerative disease and inflammatory disease .

HY-180548

MRC37	E1/E2/E3 Enzyme	Infection Inflammation/Immunology
MRC37 is a potent and selective small-molecule ligand of *TRIM21* that binds the PRYSPRY domain of TRIM21. MRC37 inhibits the natural antiviral function of TRIM21 by preventing antibody neutralisation of adenovirus 5 (Adv5). MRC37 is also capable of inhibiting Trim-Away, a targeted protein degradation technology where TRIM21 is recruited to specific proteins via electroporated antibodies .

HY-180654

JWZ-8-103	Molecular Glues Drug Derivative E1/E2/E3 Enzyme	Cancer
JWZ-8-103 is an orally active PRLX-93936 (HY-119264) analog and *TRIM21*-targeting molecular glue. JWZ-8-103 increases the thermal stability of *TRIM21. JWZ-8-103 promotes a robust and rapid interaction between TRIM21* and NUP98 (apparent EC₅₀ = ∼20 μM for TRIM21 PRYSPRY and NUP98 APD). JWZ-8-103 has anti-cancer effects against pancreatic cancer .

HY-180654A

JWZ-8-103 hydrochloride	Molecular Glues Drug Derivative E1/E2/E3 Enzyme	Cancer
JWZ-8-103 hydrochloride is an orally active PRLX-93936 (HY-119264) analog and *TRIM21*-targeting molecular glue. JWZ-8-103 hydrochloride increases the thermal stability of *TRIM21. JWZ-8-103 hydrochloride promotes a robust and rapid interaction between TRIM21* and NUP98 (apparent EC₅₀ = ∼20 μM for TRIM21 PRYSPRY and NUP98 APD). JWZ-8-103 hydrochloride has anti-cancer effects against pancreatic cancer .

HY-P992382

IC 100	Interleukin Related	Neurological Disease Inflammation/Immunology
IC 100 is a humanized IgG4κ monoclonal antibody targeting apoptosis-associated speck-like protein (ASC) with blood-brain barrier permeability. IC 100 specifically inhibits ASC after being endocytosed via its Fc segment, blocks ASC polymerization and inflammasome activation, suppresses IL-1β release, forms complexes with ASC and TRIM21, and evades TRIM21-mediated proteasomal degradation. IC 100 alleviates symptoms associated with autoimmune encephalomyelitis, reduces immune cell infiltration and microglial activation in the mouse EAE model. IC 100 is suitable for research on neuroinflammatory and inflammasome-related diseases such as multiple sclerosis. Isotype comparison: HY-P99003 .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992382

IC 100	Interleukin Related	Neurological Disease Inflammation/Immunology
IC 100 is a humanized IgG4κ monoclonal antibody targeting apoptosis-associated speck-like protein (ASC) with blood-brain barrier permeability. IC 100 specifically inhibits ASC after being endocytosed via its Fc segment, blocks ASC polymerization and inflammasome activation, suppresses IL-1β release, forms complexes with ASC and TRIM21, and evades TRIM21-mediated proteasomal degradation. IC 100 alleviates symptoms associated with autoimmune encephalomyelitis, reduces immune cell infiltration and microglial activation in the mouse EAE model. IC 100 is suitable for research on neuroinflammatory and inflammasome-related diseases such as multiple sclerosis. Isotype comparison: HY-P99003 .

Species:	Human (1) Mouse (1)
Tag:	SUMO (1) His (2)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71791

	TRIM21 Protein, Human (P.pastoris, His) 1 Publications Verification 52kDa ribonucleoprotein autoantigen Ro/SS-A; SS-A; SSA; TRIM21; Tripartite motif protein TRIM21; Tripartite motif-containing 21; Tripartite motif-containing protein 21	Human	P. pastoris
	TRIM21 Protein, an E3 ubiquitin ligase, plays a vital role in the immune response by targeting intracellular pathogens for degradation. It is involved in the recognition and clearance of viral particles. The therapeutic potential of targeting TRIM21 Protein in infectious diseases and its role in host defense make it a subject of interest in biomedical research. TRIM21 Protein, Human (P.pastoris, His) is the recombinant human-derived TRIM21 protein, expressed by P. pastoris , with N-His labeled tag.

HY-P71570

	TRIM21 Protein, Mouse (His-SUMO) TRIM21; Ro52; Ssa1; E3 ubiquitin-protein ligase TRIM21; EC 2.3.2.27; 52kDa Ro protein; 52kDa ribonucleoprotein autoantigen Ro/SS-A; RING-type E3 ubiquitin transferase TRIM21; Ro(SS-A); Sjoegren syndrome type A antigen; SS-A; Tripartite motif-containing protein 21	Mouse	E. coli
	TRIM21 is an E3 ubiquitin protein ligase that forms complexes with E2 enzymes including UBE2D1 and UBE2E2.It cooperates with UBE2D2 to ubiquitinate USP4, IKBKB and itself, and binds to SCF E3 ligase to mediate ubiquitination of CDKN1B.TRIM21 Protein, Mouse (His-SUMO) is the recombinant mouse-derived TRIM21 protein, expressed by E.coli , with N-His, N-SUMO labeled tag.

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Host:	Mouse (3)
Reactivity:	Human (3)
Application:	ICC/IF (1) WB (3)
Isotype:	IgG1 (2) IgG2b (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87632

	TRIM21 Antibody (YA7316)	WB, ICC/IF	Human
	TRIM21 Antibody (YA7316) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TRIM21.

HY-P80921

	TRIM21 Antibody (YA658) SSA; RO52; SSA1; RNF81; Ro/SSA	WB	Human
	TRIM21 Antibody (YA658) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIM21.

HY-P80921A

	TRIM21 Antibody (YA658)(PBS only) SSA; RO52; SSA1; RNF81; Ro/SSA	WB	Human
	TRIM21 Antibody (YA658) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIM21.

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TRIM21 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TRIM21 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM21 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trim21 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Trim21 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trim21 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trim21 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Trim21 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trim21 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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