3095569-91-5
Chemical Structure
TrimTAC1
- CAS No.: 3095569-91-5
- Formula:C43H47ClN8O2S2
- Molecular Weight:807.47
InChIKey: WLMVBFIVORBBQJ-UMSFTDKQSA-N
SMILES: O=C(NCCCN1CCN(CCCN2C(C=CC=C3)=C3SC4=C2C=C(C(C)=O)C=C4)CC1)C[C@H]5C6=NN=C(N6C7=C(C(C8=CC=C(C=C8)Cl)=N5)C(C)=C(S7)C)C
Biological Activity: TrimTAC1 is a TRIM21-based PROTAC degrader targeting BRD4, with a DC50 of 0.649 nM. TrimTAC1 selectively degrades multimeric proteins, including those localized in biomolecular condensates, while exerting no effect on monomeric proteins in the dilute phase. This degradation effect can be blocked by Bortezomib (HY-10227) or TAK-243 (HY-100487). TrimTAC1 can be used in research related to pancreatic cancer and autoimmune diseases[1][2].
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TrimTAC1 | TrimTAC1 is a TRIM21-based PROTAC degrader targeting BRD4, with a DC50 of 0.649 nM. TrimTAC1 selectively degrades multimeric proteins, including those localized in biomolecular condensates, while exerting no effect on monomeric proteins in the dilute phase. This degradation effect can be blocked by Bortezomib (HY-10227) or TAK-243 (HY-100487). TrimTAC1 can be used in research related to pancreatic cancer and autoimmune diseases. | |||||||||||||||||||||
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- [1]. Zhang L, et al. TRIM21-Driven Degradation of BRD4: Development of Heterobifunctional Degraders and Investigation of Recruitment and Selectivity Mechanisms. Journal of chemical information and modeling. 2025 Jul 28;65(14):7584-7604. [Content Brief]
- [2]. Lu P, et al. Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders. Cell. 2024 Dec 12;187(25):7126-7142.e20. [Content Brief]
Keywords
