dTAG-TRIMTAC 

dTAG-TRIMTAC is a PROTAC-like degrader targeting TRIM21. dTAG-TRIMTAC forms a ternary complex with TRIM21 and target proteins to drive degradation of oligomeric/assembled substrates via TRIM21 clustering-based activation, with degradation dependent on endogenous TRIM21. dTAG-TRIMTAC can be used for the research of neurodegenerative disease and inflammatory disease^[1].

dTAG-TRIMTAC (5 μM) selectively degrades oligomeric Myddosome-associated Myd88-GyrB-mEGFP-FKBP(F36V) in Coumermycin-stimulated U2OS cells, with no activity against monomeric Myd88-GyrB-mEGFP-FKBP(F36V) in unstimulated cells^[1].
dTAG-TRIMTAC (0.16-2.5 μM; 8-48 h) selectively degrades oligomeric Necrosome-associated FKBP(F36V)-mEGFP-RIPK3 in T/S/Z-stimulated RPE-1 cells, with no activity against monomeric FKBP(F36V)-mEGFP-RIPK3 in unstimulated cells, and partially inhibits necroptotic cell death^[1].
dTAG-TRIMTAC (0.11-10 μM; 1 h pre-incubation) dose-dependently inhibits seeded P301S tau aggregation in HEK293 reporter cells, achieving up to 60% inhibition^[1].
dTAG-TRIMTAC selectively degrades oligomeric Cavin1-mEGFP-FKBP(F36V) in a TRIM21-dependent manner, with no activity against monomeric mEGFP-FKBP(F36V)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1400.69

C₇₇H₁₀₅N₇O₁₇

3070832-72-0

COC(C=C1CC[C@H](C2=C(OCC(NCCCOCCOCCOCCCNC([C@@H](NC([C@H]3N(C(C[C@H](N)C4=C(OC)C=CC=C4)=O)C[C@H](C5CCCCC5)C3)=O)CC6=CC=NC=C6)=O)=O)C=CC=C2)OC([C@@H]7CCCCN7C([C@H](C8=CC(OC)=C(OC)C(OC)=C8)CC)=O)=O)=C(C=C1)OC

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• [1]. Luptak J, et al. State-selective small molecule degraders that preferentially remove aggregates and oligomers. Nat Commun. 2025;16(1):10486. Published 2025 Nov 25.  [Content Brief]