country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-185652

Copy Link Print Information

dTAG-TRIMTAC

dTAG-TRIMTAC is a PROTAC-like degrader targeting TRIM21. dTAG-TRIMTAC forms a ternary complex with TRIM21 and target proteins to drive degradation of oligomeric/assembled substrates via TRIM21 clustering-based activation, with degradation dependent on endogenous TRIM21. dTAG-TRIMTAC can be used for the research of neurodegenerative disease and inflammatory disease.

For research use only. We do not sell to patients.

CAS No.: 3070832-72-0
Formula: C₇₇H₁₀₅N₇O₁₇
Molecular Weight:1400.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

dTAG-TRIMTAC Chemical Structure

CAS No.: 3070832-72-0

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PROTACs Isoforms :

In Vitro

dTAG-TRIMTAC (5 μM) selectively degrades oligomeric Myddosome-associated Myd88-GyrB-mEGFP-FKBP(F36V) in Coumermycin-stimulated U2OS cells, with no activity against monomeric Myd88-GyrB-mEGFP-FKBP(F36V) in unstimulated cells^[1].
dTAG-TRIMTAC (0.16-2.5 μM; 8-48 h) selectively degrades oligomeric Necrosome-associated FKBP(F36V)-mEGFP-RIPK3 in T/S/Z-stimulated RPE-1 cells, with no activity against monomeric FKBP(F36V)-mEGFP-RIPK3 in unstimulated cells, and partially inhibits necroptotic cell death^[1].
dTAG-TRIMTAC (0.11-10 μM; 1 h pre-incubation) dose-dependently inhibits seeded P301S tau aggregation in HEK293 reporter cells, achieving up to 60% inhibition^[1].
dTAG-TRIMTAC selectively degrades oligomeric Cavin1-mEGFP-FKBP(F36V) in a TRIM21-dependent manner, with no activity against monomeric mEGFP-FKBP(F36V)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3070832-72-0
Molecular Weight 1400.69
Formula C₇₇H₁₀₅N₇O₁₇
SMILES

COC(C=C1CC[C@H](C2=C(OCC(NCCCOCCOCCOCCCNC([C@@H](NC([C@H]3N(C(C[C@H](N)C4=C(OC)C=CC=C4)=O)C[C@H](C5CCCCC5)C3)=O)CC6=CC=NC=C6)=O)=O)C=CC=C2)OC([C@@H]7CCCCN7C([C@H](C8=CC(OC)=C(OC)C(OC)=C8)CC)=O)=O)=C(C=C1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Luptak J, et al. State-selective small molecule degraders that preferentially remove aggregates and oligomers. Nat Commun. 2025;16(1):10486. Published 2025 Nov 25. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

dTAG-TRIMTAC

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

dTAG-TRIMTAC Related Classifications

HY-185652 Related Classifications