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製品番号: HY-185652

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dTAG-TRIMTAC

Name: dTAG-TRIMTAC
Brand: MedChemExpress
SKU: HY-185652
Price: 900.00 USD
Availability: InStock
Rating: 5 (1 reviews)

dTAG-TRIMTAC is a PROTAC-like degrader targeting TRIM21. dTAG-TRIMTAC forms a ternary complex with TRIM21 and target proteins to drive degradation of oligomeric/assembled substrates via TRIM21 clustering-based activation, with degradation dependent on endogenous TRIM21. dTAG-TRIMTAC can be used for the research of neurodegenerative disease and inflammatory disease.

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CAS 番号: 3070832-72-0
分子式: C₇₇H₁₀₅N₇O₁₇
分子量:1400.69

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

dTAG-TRIMTAC 構造式

CAS 番号: 3070832-72-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PROTACs アイソフォーム固有の製品をすべて表示 :

体外実験

dTAG-TRIMTAC (5 μM) selectively degrades oligomeric Myddosome-associated Myd88-GyrB-mEGFP-FKBP(F36V) in Coumermycin-stimulated U2OS cells, with no activity against monomeric Myd88-GyrB-mEGFP-FKBP(F36V) in unstimulated cells^[1].
dTAG-TRIMTAC (0.16-2.5 μM; 8-48 h) selectively degrades oligomeric Necrosome-associated FKBP(F36V)-mEGFP-RIPK3 in T/S/Z-stimulated RPE-1 cells, with no activity against monomeric FKBP(F36V)-mEGFP-RIPK3 in unstimulated cells, and partially inhibits necroptotic cell death^[1].
dTAG-TRIMTAC (0.11-10 μM; 1 h pre-incubation) dose-dependently inhibits seeded P301S tau aggregation in HEK293 reporter cells, achieving up to 60% inhibition^[1].
dTAG-TRIMTAC selectively degrades oligomeric Cavin1-mEGFP-FKBP(F36V) in a TRIM21-dependent manner, with no activity against monomeric mEGFP-FKBP(F36V)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3070832-72-0
分子量 1400.69
分子式 C₇₇H₁₀₅N₇O₁₇
SMILES

COC(C=C1CC[C@H](C2=C(OCC(NCCCOCCOCCOCCCNC([C@@H](NC([C@H]3N(C(C[C@H](N)C4=C(OC)C=CC=C4)=O)C[C@H](C5CCCCC5)C3)=O)CC6=CC=NC=C6)=O)=O)C=CC=C2)OC([C@@H]7CCCCN7C([C@H](C8=CC(OC)=C(OC)C(OC)=C8)CC)=O)=O)=C(C=C1)OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Luptak J, et al. State-selective small molecule degraders that preferentially remove aggregates and oligomers. Nat Commun. 2025;16(1):10486. Published 2025 Nov 25. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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