3070832-72-0
Chemical Structure
dTAG-TRIMTAC
- CAS No.: 3070832-72-0
- Formula:C77H105N7O17
- Molecular Weight:1400.69
InChIKey: LJVOIPHXVBIDRR-SFDLQOEVSA-N
SMILES: COC(C=C1CC[C@H](C2=C(OCC(NCCCOCCOCCOCCCNC([C@@H](NC([C@H]3N(C(C[C@H](N)C4=C(OC)C=CC=C4)=O)C[C@H](C5CCCCC5)C3)=O)CC6=CC=NC=C6)=O)=O)C=CC=C2)OC([C@@H]7CCCCN7C([C@H](C8=CC(OC)=C(OC)C(OC)=C8)CC)=O)=O)=C(C=C1)OC
Biological Activity: dTAG-TRIMTAC is a PROTAC-like degrader targeting TRIM21. dTAG-TRIMTAC forms a ternary complex with TRIM21 and target proteins to drive degradation of oligomeric/assembled substrates via TRIM21 clustering-based activation, with degradation dependent on endogenous TRIM21. dTAG-TRIMTAC can be used for the research of neurodegenerative disease and inflammatory disease[1].
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dTAG-TRIMTAC | dTAG-TRIMTAC is a PROTAC-like degrader targeting TRIM21. dTAG-TRIMTAC forms a ternary complex with TRIM21 and target proteins to drive degradation of oligomeric/assembled substrates via TRIM21 clustering-based activation, with degradation dependent on endogenous TRIM21. dTAG-TRIMTAC can be used for the research of neurodegenerative disease and inflammatory disease. | |||||||||||||||||||||
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Keywords
