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Cat. No.: HY-D3457

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Tracer AL244

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Tracer AL244 is a BODIPY-based fluorescent tracer and also a TRIM21 binder. Tracer AL244 enables evaluation of TRIM21 target binding in both intact and permeabilized cells.

For research use only. We do not sell to patients.

Formula: C₄₆H₅₆BF₃N₆O₇S₂
Molecular Weight:936.91

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Tracer AL244 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Tracer AL244 is a BODIPY-based fluorescent tracer and also a TRIM21 binder. Tracer AL244 enables evaluation of TRIM21 target binding in both intact and permeabilized cells^[1].

In Vitro

Tracer AL244 (6 nM-3 µM; 2 h) generates strong BRET signals in HEK293T cells expressing full-length human TRIM21 with a C-terminally fused NanoLuc, enabling live-cell target binding assays^[1].
Tracer AL244 generates strong BRET signals and a favorable assay window when interacting with C-terminally fused NanoLuc-TRIM21, whereas it produces weak signals when interacting with N-terminally fused NanoLuc-TRIM21^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Molecular Weight 936.91
Formula C₄₆H₅₆BF₃N₆O₇S₂
SMILES

CSC1=CC(F)=CC=C1C2=CC(S(C)(=O)=O)=C(C=C2)C(NCCC3CCN(CCOCCOCCOCCNC(CCC4=CC=C5N4[B-](F)(F)[N+]6=C(C7=CC=CN7)C=CC6=C5)=O)CC3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kim Y, et al. Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain. Communications chemistry. 2025 Jun 13;8(1):185. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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