1 Result for "

actin oligomers

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "actin oligomers" in MCE Product Catalog:

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Phallacidin
Phallacidin
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Cat. No.: HY-P2031
CAS No.: 26645-35-2
Category:  

Microorganisms Ketones, Aldehydes, Acids Other Diseases Disease Research Fields

Target:  

Arp2/3 Complex

Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a Kd of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy .
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