26645-35-2
Chemical Structure
Phallacidin
- CAS No.: 26645-35-2
- Formula:C37H50N8O13S
- Molecular Weight:846.90
InChIKey: KUBDTFZQCYLLGC-AASPPYRUSA-N
SMILES: O=C1N[C@H](C(N[C@H](C(N[C@@]([C@H](O)C(O)=O)([H])C(N[C@@]2([H])CSC3=C(C4=C(C=CC=C4)N3)C[C@]1([H])NC([C@@H](NC([C@@]5([H])N(C[C@@H](O)C5)C2=O)=O)C)=O)=O)=O)C(C)C)=O)CC(C)(O)CO
Biological Activity: Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a Kd of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phallacidin | 92.4% | Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a Kd of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy. | ||||||||||||||||||||
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References
- [1]. Phillips PG, et al. Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin. Am J Physiol. 1989;257(3 Pt 1):C562-C567. [Content Brief]
- [2]. Sampson K, et al. Phallacidin stains the mitotic spindle of the diatom Pinnularia spp. Cell Biol Int. 2004;28(8-9):565-569. [Content Brief]
