7 Results for "

aggregated IgG

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "aggregated IgG" in MCE Product Catalog:

Cat. No.: HY-P99405
CAS No.: 1960462-19-4
Synonyms: PRX 002; RG 7935; RO 7046015

Target:  

α-synuclein

Research Areas:  

Neurological Disease

Prasinezumab (PRX 002) is a humanized IgG1 monoclonal antibody directed against aggregated α-synuclein. Prasinezumab has the potential for Parkinson's disease research .
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Cat. No.: HY-P990109

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Aducanumab (Mouse IgG2a) is a monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). The variable region of Aducanumab (Mouse IgG2a) is consistent with that of Aducanumab (HY-P9967), while the constant region is of Mouse IGG2a sequence. Aducanumab (Mouse IgG2a) has strong selectivity for Aβ fibrils with EC50s of >1 μM and 0.2 nM for monomeric Aβ1-40 and fibrillar Aβ1-42, respectively. Aducanumab (Mouse IgG2a) can be used for Alzheimer's disease (AD) research .
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Cat. No.: HY-P99720A
CAS No.: 1373715-00-4
Synonyms: RAP-536

Target:  

TGF-beta/Smad

Research Areas:  

Metabolic Disease

Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human ActRIIB linked to the murine IgG2a Fc domain. Luspatercept (mIgG2a) inhibits Smad2/3 signaling, promotes differentiation of late-stage erythroid precursors and mitigates ineffective erythropoiesis (IE) in murine β-thalassemia. Luspatercept (mIgG2a) reduces anemia, α-globin aggregates, hemolysis, and disease complications of IE such as iron overload, splenomegaly, and bone defects .
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Cat. No.: HY-P991073

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

MEDI-1814 is a fully human IgG1 antibody that targets the C terminus of Aβ42. MEDI-1814 binds to and sweeps away the circulated Aβ peptides, hence, restricting them from aggregating into toxic oligomers. MEDI-1814 can be used for the study of Alzheimer's diseases. The isotype control for MEDI-1814 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-163057
CAS No.: 929540-19-2
Target:  

Hapten

Research Areas:  

Inflammation/Immunology

2,2',2''-Nitrilotris(NH-EG8-Lys-2,4-dinitroaniline) is a trivalent hapten. 2,2',2''-Nitrilotris(NH-EG8-Lys-2,4-dinitroaniline) can aggregate with monoclonal anti-2,4-DNP IgG (IgGDNP) .
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Cat. No.: HY-D3274
PE-Cy5 is a tandem fluorescent dye commonly used in flow cytometry, immunofluorescence, and cell biology research. It is formed by the covalent linkage of two fluorescent molecules, namely phycoerythrin and CY5. PE-Cy5 binds to human FcγRI (CD64), and this binding can be blocked by human pooled serum, anti-CD64 monoclonal antibodies targeting the ligand-binding region, or aggregated IgG. PE-Cy5 supports three-color flow cytometry analysis, and whole blood staining can partially reduce its non-specific binding (Ex/Em = 450-500 nm/665 nm) .
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Cat. No.: HY-P991957

Target:  

Prion Protein

Research Areas:  

Neurological Disease

PRN100 is a fully humanized anti-prion protein (PrPᶜ) monoclonal antibody belonging to the IgG isotype. By binding to and stabilizing cellular prion protein, PRN100 aims to prevent the recruitment and conversion of cellular prion protein into pathogenic, self-propagating prion (PrPˢᶜ) aggregates. PRN100 can be used for the research of Creutzfeldt-Jakob disease.
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