Aducanumab (Mouse IgG2a)
Based on 1 Customer Validation
Aducanumab (Mouse IgG2a) is a monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). The variable region of Aducanumab (Mouse IgG2a) is consistent with that of Aducanumab (HY-P9967), while the constant region is of Mouse IGG2a sequence. Aducanumab (Mouse IgG2a) has strong selectivity for Aβ fibrils with EC50s of >1 μM and 0.2 nM for monomeric Aβ1-40 and fibrillar Aβ1-42, respectively. Aducanumab (Mouse IgG2a) can be used for Alzheimer's disease (AD) research.
For research use only. We do not sell to patients.
- Purity: 99%
- Molecular Weight:147.019 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Mouse IgG2a kappa
Human
Aducanumab (Mouse IgG2a) (0.31-40 μM, 2 min) has extremely weak monovalent binding, with a KD of ~9 μM for its Fab for surface-captured monomeric Aβ1-40-biotin[1].
Aducanumab (Mouse IgG2a) (5 μM) shows very weak affinity with Aβ peptide with KDs of 1.8 and 5.9 μM for Aβ1-16 and Aβ1-28 peptide[1].
Aducanumab (Mouse IgG2a) had weak affinity with imeric and tetrameric multi-antigen peptides (MAPs) with EC50s of > 1 μM and ~7 nM for dimeric and tetrameric Aβ1-15 MAP, respectively[1].
Aducanumab (Mouse IgG2a) efficiently binds the immobilized Aβ in a surplus of free monomer with IC50 of >1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Appearance Liquid
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Molecular Weight 147.019 kDa
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Color Colorless to light yellow
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SMILES
[Aducanumab (Mouse IgG2a)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aducanumab (Mouse IgG2a) Related Classifications
HY-P990109 Related Classifications
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