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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
64 Results for "
alkylation
" in MedChemExpress (MCE) Product Catalog:
Products (64)
64 Results for "alkylation" in MCE Product Catalog:
154
154 Publications Verification
Synonyms: Streptozocin; NSC-85998; U 9889
98
Target:
Áreas de investigación:
4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 .
13
Target:
Áreas de investigación:
2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics .
1
1 Cited Publications
Synonyms: CBI-TMI
Áreas de investigación:
Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.
1
1
1 Cited Publications
Synonyms: Resacetophenone; 1-(2,4-Dihydroxyphenyl)ethanone
Target:
1
1 Cited Publications
Áreas de investigación:
Semustine is an orally active, blood-brain barrier permeable antitumor alkylating agent with a binding affinity of 1.53 × 10 3 M -1 for guanine and thymine residues in bovine DNA. Semustine undergoes major groove-directed alkylation at guanine residues to form O6-chloroethylguanine and N1-O6-ethanoguanine adducts, and generates dG-dC interstrand crosslinks. Semustine induces partial B- to C-type transition of DNA, base stacking and helical structure distortion, mild dehydration, as well as partial DNA double-strand unwinding. Semustine can be used in research related to Lewis lung cancer, leukemia, Hodgkin's lymphoma, malignant melanoma, glioma, and diffuse large B-cell lymphoma .
Áreas de investigación:
Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM . Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro .
Referencia número: HY-W021005
No. CAS: 189114-61-2
Synonyms: Silver triflimide
Áreas de investigación:
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels .
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target:
Áreas de investigación:
DMF-DMA (N-Dimethoxymethyl-N,N-dimethylamine) is a reagent with both condensation and alkylation functions. DMF-DMA can undergo condensation reactions with active methylene groups or amino groups to generate enamine and imino derivatives, and can also act as an alkylating agent to methylate nitrogen and oxygen atoms in heterocyclic structures. DMF-DMA is widely used in the synthesis of enaminones and dimethylamino imine intermediates, as well as in the construction of heterocyclic backbones such as pyridine, pyrimidine and pyrazole. DMF-DMA can also serve as a polar aprotic co-solvent; although DMF-DMA cannot dissolve cellulose alone, it can form an efficient cellulose dissolution system with diallylimidazolium methoxyacetate .
Category:
Target:
Referencia número: HY-34477S1
No. CAS: 1219802-64-8
Synonyms: Iodoacetamide-d4
Referencia número: HY-76667
No. CAS: 83948-53-2
Áreas de investigación:
3-(Boc-amino) propyl bromide is an alkylating reagent used for the N-alkylation of benzopyranotriazolopyrimidine-based MDM2-p53 protein-protein inhibitor 4 to prepare Compound 13 .
Referencia número: HY-W015179
No. CAS: 20031-21-4
Synonyms: Monoacetone-D-xylose
Áreas de investigación:
2-Iodoacetamide (Standard) is the analytical standard of 2-Iodoacetamide. This product is intended for research and analytical applications. 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics .
Referencia número: HY-W741573
No. CAS: 212391-23-6
Target:
Áreas de investigación:
N-Biotinyl p-aminophenyl arsenic acid is a bifunctional reagent that can bind to both streptavidin and dithiols. N-Biotinyl p-aminophenyl arsenic acid decreases the Rbungarotoxin-binding sites in reduced Torpedo nicotinic receptors (IC50 is 10-300 nM), and protects the receptor from irreversible alkylation by bromoacetylcholine .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
