89-84-9
89-84-9
Chemical Structure
2',4'-Dihydroxyacetophenone
Synonym(s): Resacetophenone; 1-(2,4-Dihydroxyphenyl)ethanone
- No. CAS: 89-84-9
- Formula:C8H8O3
- Molecular Weight:152.15
IUPAC Name: 1-(2,4-dihydroxyphenyl)ethan-1-one
InChIKey: SULYEHHGGXARJS-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(O)C=C1O)=O
Biological Activity: 2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. 2',4'-Dihydroxyacetophenone involves in a practical CsHCO3-mediated alkylation that efficiently provide 4-alkylated products with excellent regioselectivity, good isolated yields and a broad substrate scope. 2',4'-Dihydroxyacetophenone is a plant metabolite[1][2][3].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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2',4'-Dihydroxyacetophenone | 99.94% | 2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. 2',4'-Dihydroxyacetophenone involves in a practical CsHCO3-mediated alkylation that efficiently provide 4-alkylated products with excellent regioselectivity, good isolated yields and a broad substrate scope. 2',4'-Dihydroxyacetophenone is a plant metabolite. | ||||||||||||||||||||
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2',4'-Dihydroxyacetophenone (Standard) | ≥98% | 2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. 2',4'-Dihydroxyacetophenone involves in a practical CsHCO3-mediated alkylation that efficiently provide 4-alkylated products with excellent regioselectivity, good isolated yields and a broad substrate scope. 2',4'-Dihydroxyacetophenone is a plant metabolite. | ||||||||||||||||||||
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1-(4-Chloro-2-hydroxyphenyl)ethan-1-one | 99.0% | 1-(4-Chloro-2-hydroxyphenyl)ethan-1-one is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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2'-Hydroxy-4'-methylacetophenone | 99.76% | 2'-Hydroxy-4'-methylacetophenone is an acetophenone (HY-Y0989) derivative and acaricide that can be isolated from the roots of Angelica koreana. 2'-Hydroxy-4'-methylacetophenone exhibits toxicity against mites. It serves as a starting material for the synthesis of flavonoid derivatives. 2'-Hydroxy-4'-methylacetophenone can be used in studies related to infestations of house dust mites and stored food mites. | ||||||||||||||||||||
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3',4'-Dihydroxyacetophenone | 99.87% | 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a phenolic compound with oral bioavailability, possessing potent antioxidant, anti-inflammatory, anticancer and cardiovascular protective activities. 3',4'-Dihydroxyacetophenone inhibits mushroom Tyrosinase activity with an IC50 of 10 μM, thereby suppressing melanogenesis. 3',4'-Dihydroxyacetophenone inhibits platelet aggregation in platelet-rich plasma. 3',4'-Dihydroxyacetophenone reduces ROS levels in human umbilical vein endothelial cells treated with high glucose, upregulates the expression of Nrf2, HO-1 and PARP-1 in cells, and promotes the nuclear translocation of Nrf2. 3',4'-Dihydroxyacetophenone induces autophagy and apoptosis. 3',4'-Dihydroxyacetophenone inhibits seed germination/growth in most plants. 3',4'-Dihydroxyacetophenone can be used in the research of cancer, neurodegenerative diseases, non-alcoholic steatohepatitis, diabetes, obesity, skin pigmentation disorders, and cardiovascular and cerebrovascular diseases. | ||||||||||||||||||||
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2,5-Dihydroxyacetophenone (Standard) | ≥98% | 2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways. | ||||||||||||||||||||
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5′-Chloro-2′-hydroxyacetophenone | 98.0% | 5′-Chloro-2′-hydroxyacetophenone is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Acebutolol impurity 5 | Acebutolol impurity 5 is an impurity of Acebutolol. | |||||||||||||||||||||
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4′-Hydroxy-2′-methylacetophenone | 99.67% | 4′-Hydroxy-2′-methylacetophenone is an aroma compound in red wine, which can be isolated from the cv. Bobal grape variety. 4′-Hydroxy-2′-methylacetophenone accumulates in adipose tissues and exerts non-specific membrane effects on Tetrahymena pyriformis. 4′-Hydroxy-2′-methylacetophenone inhibits the growth of Tetrahymena pyriformis. | ||||||||||||||||||||
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2,4-Dihydroxybenzoic acid | 99.90% | 2,4-Dihydroxybenzoic acid is a degradation product of acid cherry anthocyanins during in vitro cell culture and an analogue of coenzyme Q precursor molecules. 2,4-Dihydroxybenzoic acid can improve the related symptoms of kidney diseases caused by ADCK4/Coq6 deficiency. | ||||||||||||||||||||
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2'-Hydroxy-5'-methylacetophenone | 99.97% | 2'-Hydroxy-5'-methylacetophenone belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group. | ||||||||||||||||||||
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2,6-Dihydroxyacetophenone (Standard) | ≥98% | 2,6-Dihydroxyacetophenone (Standard) is the analytical standard of 2,6-Dihydroxyacetophenone (HY-Y0106). This product is intended for research and analytical applications. 2,6-Dihydroxyacetophenone, a polyphenolic derivative of Acetophenone (HY-Y0989), is an orally active mTOR inhibitor. 2,6-Dihydroxyacetophenone shows antioxidant activity. 2,6-Dihydroxyacetophenone inhibits cell growth and proliferation in CRC cells. 2,6-Dihydroxyacetophenone arrests at G0/G1 phase of cell cycle, induces apoptosis and suppresses cell migration in CRC cells. 2,6-Dihydroxyacetophenone inhibits xanthine oxidase (XOD) with an IC50 of 1.24 mM. 2,6-dihydroxyacetophenone improves uric acid metabolism in hyperuricemia mice, reduces plasma cholesterol in hypercholesterolemic rats, and inhibits lipid accumulation in HFD-induced obese mice. 2,6-Dihydroxyacetophenone can be used for the study of colorectal cancer (CRC), hyperuricemia and hypercholesterolemia. | ||||||||||||||||||||
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References
- [1]. Li XJ, et al. Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor. Nat Prod Commun. 2011 Aug;6(8):1129-30. [Content Brief]
- [2]. Baughman RG, et al. 2,4-Dinitrophenylhydrazones of 2,4-dihydroxybenzaldehyde, 2,4-dihydroxyacetophenone and 2,4-dihydroxybenzophenone. Acta Crystallogr C. 2004 Feb;60(Pt 2):o103-6. [Content Brief]
- [3]. Frank A, et al. Regioselective alkylation of 2,4-dihydroxybenzyaldehydes and 2,4-dihydroxyacetophenones. Tetrahedron Lett. 2022 Apr 13;95:153755. [Content Brief]
