2'-Hydroxy-4'-methylacetophenone
Based on 1 Customer Validation
2'-Hydroxy-4'-methylacetophenone is an acetophenone (HY-Y0989) derivative and acaricide that can be isolated from the roots of Angelica koreana. 2'-Hydroxy-4'-methylacetophenone exhibits toxicity against mites. It serves as a starting material for the synthesis of flavonoid derivatives. 2'-Hydroxy-4'-methylacetophenone can be used in studies related to infestations of house dust mites and stored food mites.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 6921-64-8
- Formula: C9H10O2
- Molecular Weight:150.18
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>1 x 10-4 M
Compound: 29
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Cytotoxicity against human A549 cells after 72 hrs by XTT assay
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| A549 | IC50 |
>10 x 10-5 M
Compound: 29
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Cytotoxicity against human A549 cells after 72 hrs by XTT assay
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| A549 | IC50 |
>10 × 10-5 M
Compound: 29
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Cytotoxicity against human A549 cells after 72 hrs by XTT assay
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
|
[PMID: 20619940] |
| HeLa | IC50 |
>1 x 10-4 M
Compound: 29
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Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| HeLa | IC50 |
>10 x 10-5 M
Compound: 29
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Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| HeLa | IC50 |
>10 × 10-5 M
Compound: 29
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Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| HL-60 | IC50 |
>1 x 10-4 M
Compound: 29
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Cytotoxicity against human HL60 cells after 72 hrs by XTT assay
Cytotoxicity against human HL60 cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| HL-60 | IC50 |
>10 x 10-5 M
Compound: 29
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Cytotoxicity against human HL60 cells after 72 hrs by XTT assay
Cytotoxicity against human HL60 cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| HL-60 | IC50 |
>10 × 10-5 M
Compound: 29
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Cytotoxicity against human HL60 cells after 72 hrs by XTT assay
Cytotoxicity against human HL60 cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| HT-29 | IC50 |
>1 x 10-4 M
Compound: 29
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Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| HT-29 | IC50 |
>10 x 10-5 M
Compound: 29
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Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| HT-29 | IC50 |
>10 × 10-5 M
Compound: 29
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Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
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[PMID: 20619940] |
2'-Hydroxy-4'-methylacetophenone (0.63-80 μg/cm2; 24 h) exhibits vapor phase acaricidal activity against adult Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus putrescentiae mites with LD50 values of 1.75 μg/cm2, 2.92 μg/cm2, and 3.49 μg/cm2, respectively[1].
2'-Hydroxy-4'-methylacetophenone (0.32-80 μg/cm2; 24 h) exhibits contact acaricidal activity against adult Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus putrescentiae mites with LD50 values of 0.76 μg/cm2, 1.29 μg/cm2, and 1.36 μg/cm2, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6921-64-8
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Appearance Liquid (Density: 1.08 g/cm3 )
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Molecular Weight 150.18
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Formula C9H10O2
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Color Colorless to light yellow
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SMILES
CC(C1=CC=C(C)C=C1O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (665.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.65 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.65 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Oh MS, et al. Acaricidal toxicity of 2'-hydroxy-4'-methylacetophenone isolated from Angelicae koreana roots and structure-activity relationships of its derivatives. J Agric Food Chem. 2012 Apr 11;60(14):3606-11. [Content Brief]
[2]. De Meyer N, et al. 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity. Journal of medicinal chemistry. 1991 Feb;34(2):736-46. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.6587 mL | 33.2934 mL | 66.5868 mL | 166.4669 mL |
| 5 mM | 1.3317 mL | 6.6587 mL | 13.3174 mL | 33.2934 mL | |
| 10 mM | 0.6659 mL | 3.3293 mL | 6.6587 mL | 16.6467 mL | |
| 15 mM | 0.4439 mL | 2.2196 mL | 4.4391 mL | 11.0978 mL | |
| 20 mM | 0.3329 mL | 1.6647 mL | 3.3293 mL | 8.3233 mL | |
| 25 mM | 0.2663 mL | 1.3317 mL | 2.6635 mL | 6.6587 mL | |
| 30 mM | 0.2220 mL | 1.1098 mL | 2.2196 mL | 5.5489 mL | |
| 40 mM | 0.1665 mL | 0.8323 mL | 1.6647 mL | 4.1617 mL | |
| 50 mM | 0.1332 mL | 0.6659 mL | 1.3317 mL | 3.3293 mL | |
| 60 mM | 0.1110 mL | 0.5549 mL | 1.1098 mL | 2.7744 mL | |
| 80 mM | 0.0832 mL | 0.4162 mL | 0.8323 mL | 2.0808 mL | |
| 100 mM | 0.0666 mL | 0.3329 mL | 0.6659 mL | 1.6647 mL |
2'-Hydroxy-4'-methylacetophenone Related Classifications
HY-34204 Related Classifications
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- 2'-Hydroxy-4'-methylacetophenone
- 6921-64-8
- Parasite
- flavone derivatives
- Tyrophagus putrescentiae
- stored food mite infestations
- acaricide
- Dermatophagoides pteronyssinus
- Dermatophagoides farinae
- house dust mite infestations
- Angelica koreana
- p-(benzyloxy)benzoyl chloride
- acetophenone derivative
- Inhibitor
- inhibitor
- inhibit