1149-99-1
1149-99-1
Chemical Structure
Illudin S
- CAS No.: 1149-99-1
- Formula:C15H20O4
- Molecular Weight:264.32
IUPAC Name: (2'S,3'R,6'R)-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-2',3'-dihydrospiro[cyclopropane-1,5'-inden]-7'(6'H)-one
InChIKey: DDLLIYKVDWPHJI-RDBSUJKOSA-N
SMILES: O=C1C2=C[C@](C)([C@@H](C2=C(C3([C@@]1(C)O)CC3)C)O)CO
Biological Activity: Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Illudin S | 99.80% | Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells. | ||||||||||||||||||||
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References
- [1]. Hansruedi Glatt, et al. Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. Arch Toxicol . 2014 Jan;88(1):161-9. [Content Brief]
- [2]. Nicolaas G J Jaspers, et al. Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair (Amst). 2002 Dec 5;1(12):1027-38. [Content Brief]
- [3]. Illudin S, the sole antiviral compound in mature fruiting bodies of Omphalotus illudens [Content Brief]
- [4]. M J Kelner, et al. Preclinical evaluation of illudins as anticancer agents. Cancer Res. 1987 Jun 15;47(12):3186-9. [Content Brief]
Keywords
