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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
bispecific ADC
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "bispecific ADC" in MCE Product Catalog:
Cat. No.: HY-164702
Synonyms: Izalontamab Brengitecan
Research Areas:
BL-B01D1 (Izalontamab Brengitecan) is a bispecific antibody-drug conjugate (ADC) targeting EGFR and HER3, formed by conjugating the EGFR/HER3 bispecific antibody Izalontamab (HY-P99676) to a novel TOP-I inhibitor payload Deruxtecan 2-hydroxypropanamide (HY-153891) via a cleavable linker (Mc-Gly-Gly-Phe-Gly). BL-B01D1 binds to EGFR and HER3 on the surface of tumor cells, mediates endocytosis and releases the payload, inhibits topoisomerase I, blocks DNA replication and RNA synthesis, and disrupts DNA structure. BL-B01D1 induces cell cycle S-phase arrest, apoptosis, antibody-dependent cell-mediated cytotoxicity, and tumor cell death. BL-B01D1 can be used for cancer research .
Cat. No.: HY-P991097
Synonyms: PM-8002; BNT-327
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Cat. No.: HY-178836
CAS No.: 3077488-78-6
Target:
Research Areas:
Z56-L23 is a conjugate of RAS-targeting ADC cytotoxic payload-linker with anti-tumor activity. Z56-L23 can be conjugated with HER3 antibody, EGFR antibody or EGFRxHER3 bispecific antibody to form intact antibody-drug conjugates (ADCs). ADC molecules related to Z56-L23 effectively inhibit the proliferation of tumor cells and also significantly suppress tumor growth in xenograft mouse models. Z56-L23 can be used in the research of pancreatic cancer .
Cat. No.: HY-177585
CAS No.: 3025473-38-2
Research Areas:
BLD1102 is a linker-load conjugate (Drug-Linker Conjugates for ADC) consisting of a DNA topoisomerase I inhibitor BCPT02 and a protease-cleavable linker. BLD1102 can be used to synthesize ADCs. BLD1102 can be used in cancer research .
Cat. No.: HY-156897
Purity: 98.01%
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Val-Cit-amide-Ph-Maytansine is an antibody and bispecific antigen-binding mol. that bind hepatocyte growth factor receptor c-Met (MET) or antibody-drug conjugates (ADCs) .
Cat. No.: HY-171191
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Val-Cit-amide-Cbz-N(Me)-Maytansine is an antibody and bispecific antigen-binding mol. that bind hepatocyte growth factor receptor c-Met (MET) or antibody-drug conjugates (ADCs) .
Cat. No.: HY-183523
CAS No.: 2925458-10-0
Synonyms: CPT-113
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Bis-Mal-Suc-PEG10-bis(triAla)-Exatecan (CPT-113) is a cytotoxic payload/linker conjugate that forms antibody-drug conjugates (ADCs) with bispecific EGFR/Muc1 antibodies. Bis-Mal-Suc-PEG10-bis(triAla)-Exatecan is applicable for ADC synthesis .
Cat. No.: HY-183912
CAS No.: 3054643-04-5
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PY-4Car2 is a Camptothecin (HY-16560) derivative and a topoisomerase I inhibitor. PY-4Car2 functions as a warhead conjugated via a cleavable linker to the bispecific ADC TJ101. PY-4Car2 can be used as an ADC payload for the research of cancers .
Cat. No.: HY-P992518
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
