Bis-Mal-Suc-PEG10-bis(triAla)-Exatecan
Bis-Mal-Suc-PEG10-bis (triAla)-Exatecan (CPT-113) is a cytotoxic payload/linker conjugate that forms antibody-drug conjugates (ADCs) with bispecific EGFR/Muc1 antibodies. Bis-Mal-Suc-PEG10-bis (triAla)-Exatecan is applicable for ADC synthesis.
For research use only. We do not sell to patients.
- CAS No.: 2925458-10-0
- Formula: C140H196F2N20O46
- Molecular Weight:2933.20
-
Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
More
Biological Activity
Antibody-drug conjugates (ADCs) consist of drug-linker conjugates composed of active cytotoxic drugs and appropriate linkers. After conjugation with monoclonal antibodies, these conjugates can be used to prepare ADCs, which are highly selective and cytotoxic targeted drugs against cancer cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2925458-10-0
-
Appearance Solid
-
Molecular Weight 2933.20
-
Formula C140H196F2N20O46
-
SMILES
N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCNC(C(C(C(NCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C2=C3C(C=4N(C3)C(=O)C5=C(C4)[C@](CC)(O)C(=O)OC5)=NC=6C2=C(CC1)C(C)=C(F)C6)=O)C)=O)C)=O)C)=O)CCCCNC(COCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)=O)N7C(=O)C=CC7=O)N8C(=O)C=CC8=O)=O)=O)CCCCNC(COCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)C)=O)C)=O)C)=O)[C@@H]9C%10=C%11C(C=%12N(C%11)C(=O)C%13=C(C%12)[C@](CC)(O)C(=O)OC%13)=NC=%14C%10=C(CC9)C(C)=C(F)C%14
-
Synonyms
CPT-113
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (34.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3409 mL | 1.7046 mL | 3.4092 mL | 8.5231 mL |
| 5 mM | 0.0682 mL | 0.3409 mL | 0.6818 mL | 1.7046 mL | |
| 10 mM | 0.0341 mL | 0.1705 mL | 0.3409 mL | 0.8523 mL | |
| 15 mM | 0.0227 mL | 0.1136 mL | 0.2273 mL | 0.5682 mL | |
| 20 mM | 0.0170 mL | 0.0852 mL | 0.1705 mL | 0.4262 mL | |
| 25 mM | 0.0136 mL | 0.0682 mL | 0.1364 mL | 0.3409 mL | |
| 30 mM | 0.0114 mL | 0.0568 mL | 0.1136 mL | 0.2841 mL |
Bis-Mal-Suc-PEG10-bis(triAla)-Exatecan Related Classifications
HY-183523 Related Classifications
Powered by Bioz