2925458-10-0
Chemical Structure
Bis-Mal-Suc-PEG10-bis(triAla)-Exatecan
Synonym(s): CPT-113
- CAS. Nr.: 2925458-10-0
- Formula:C140H196F2N20O46
- Molecular Weight:2933.20
IUPAC Name: 2,3-bis(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N1,N4-bis((S)-37-(((S)-1-(((S)-1-(((S)-1-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-31,39-dioxo-2,5,8,11,14,17,20,23,26,29-decaoxa-32,38-diazadotetracontan-42-yl)succinamide
InChIKey: UGXPLKUFDVJGIV-PYMOAGAXSA-N
SMILES: N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCNC(C(C(C(NCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C2=C3C(C=4N(C3)C(=O)C5=C(C4)[C@](CC)(O)C(=O)OC5)=NC=6C2=C(CC1)C(C)=C(F)C6)=O)C)=O)C)=O)C)=O)CCCCNC(COCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)=O)N7C(=O)C=CC7=O)N8C(=O)C=CC8=O)=O)=O)CCCCNC(COCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)C)=O)C)=O)C)=O)[C@@H]9C%10=C%11C(C=%12N(C%11)C(=O)C%13=C(C%12)[C@](CC)(O)C(=O)OC%13)=NC=%14C%10=C(CC9)C(C)=C(F)C%14
Biological Activity: Bis-Mal-Suc-PEG10-bis(triAla)-Exatecan (CPT-113) is a cytotoxic payload/linker conjugate that forms antibody-drug conjugates (ADCs) with bispecific EGFR/Muc1 antibodies. Bis-Mal-Suc-PEG10-bis(triAla)-Exatecan is applicable for ADC synthesis[1].
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Bis-Mal-Suc-PEG10-bis(triAla)-Exatecan | Bis-Mal-Suc-PEG10-bis(triAla)-Exatecan (CPT-113) is a cytotoxic payload/linker conjugate that forms antibody-drug conjugates (ADCs) with bispecific EGFR/Muc1 antibodies. Bis-Mal-Suc-PEG10-bis(triAla)-Exatecan is applicable for ADC synthesis. | |||||||||||||||||||||
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