132 Results for "

block polymers

" in MedChemExpress (MCE) Product Catalog:
Products (132)

132 Results for "block polymers" in MCE Product Catalog:

47
47 Publications Verification
Cat. No.: HY-16928
CAS No.: 14930-96-2
Synonyms: Phomin
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with Kd value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.
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17
17 Cited Publications
Cat. No.: HY-Y0479
CAS No.: 79-33-4
Synonyms: (S)-2-Hydroxypropanoic acid
L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid has antiproliferative activity .
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17
17 Cited Publications
Cat. No.: HY-W040233
CAS No.: 867-56-1
Synonyms: (S)-2-Hydroxypropanoic acid sodium
L-lactate Sodium (Sodium (S)-2-hydroxypropanoate) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activity .
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13
13 Cited Publications
Cat. No.: HY-16929
CAS No.: 76343-93-6
Synonyms: LAT-A
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .
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12
12 Cited Publications
Cat. No.: HY-D0884
CAS No.: 27848-80-2
Synonyms: (S)-2-Hydroxypropanoic acid lithium
L-Lactic acid lithium ((S)-2-Hydroxypropanoic acid lithium) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid lithium has antiproliferative activity .
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12
12 Cited Publications
Cat. No.: HY-W105639
CAS No.: 865717-20-0
Target:  

Drug Intermediate

Research Areas:  

Others

L-Lactic acid calcium hydrate is the calcium salt of L-Lactic acid. L-Lactic acid calcium hydrate is a building block that can be used as a precursor for the production of bioplastic polymer polylactic acid .
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7
7 Cited Publications
Cat. No.: HY-B0294
CAS No.: 31430-15-6
Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites .
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4
4 Cited Publications
Cat. No.: HY-15892
CAS No.: 442632-72-6
Purity:  99.95%
Synonyms: CK-0944636
Target:  

Arp2/3 Complex

Research Areas:  

Inflammation/Immunology Cancer

CK-636 is a cell permeable inhibitor of Arp2/3 complex, that could inhibit actin polymerization, with IC50 values of 4 μM, 24 μM and 32 μM for human, fission yeast and bovine, respectively. CK636 blocks cell migration.
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3
3 Cited Publications
Cat. No.: HY-P9980
CAS No.: 2061894-48-0
Synonyms: GSK2857914

Research Areas:  

Cancer

Belantamab (GSK2857916) is a humanized IgG1 anti-BCMA/TNFRSF17 monoclonal antibody. Belantamab is linked to MMAF (HY-15579) through a non-cleavable ADC linker to synthesize the antibody-active molecule conjugate (ADC) Belantamab mafodotin (HY-P3239). After binding to BCMA on the surface of tumor cells, Belantamab mafodotin enters the cell through receptor-mediated endocytosis. After entering the cell, Belantamab mafodotin releases MMAF, blocks cell division by inhibiting tubulin polymerization, arrests the cell cycle and induces cell apoptosis. Belantamab can be used for the study of multiple myeloma, especially relapsed/refractory multiple myeloma .
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1
1 Cited Publications
Cat. No.: HY-125527
CAS No.: 872993-05-0
Purity:  ≥99.0%
Synonyms: RvD1
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .
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1
1 Cited Publications
Cat. No.: HY-Y0479AS2
CAS No.: 201595-69-9
Synonyms: (S)-2-Hydroxypropanoic acid-13C sodium
L-Lactate- 13C ((S)-2-Hydroxypropanoic acid- 13C) sodium is the 13C-labeled L-Lactic acid sodium (HY-W040233). L-lactate Sodium is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activity .
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1
1 Cited Publications
Cat. No.: HY-148775B
Purity:  ≥95.0%
PLGA-PEG-MAL (20KDA-5.0KDA, LA:GA RATIO 40:60) is a biodegradable amphipathic polymeric nanocarrier of poly (lactic-co-glycolic acid)-block-poly (ethylene glycol) (PLGA-PEG-Mal) that allows covalent modification of functional molecules. PLGA-PEG-MAL (20KDA-5.0KDA, LA:GA RATIO 40:60) modified with Angiopep-2 can cross the blood-brain barrier and exhibits targeting selectivity for glioblastoma cells. PLGA-PEG-MAL (20KDA-5.0KDA, LA:GA RATIO 40:60) can capture tumor-derived protein antigens, and exerts immunomodulatory effects when conjugated with anti-OX40 antibody; when used in combination with A2-CL/Dbait nanoparticles and radiotherapy, it prolongs survival time and reduces tumor volume in glioblastoma mouse models. PLGA-PEG-MAL (20KDA-5.0KDA, LA:GA RATIO 40:60) can be used for studies related to bacterial wound infections and glioblastoma .
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Cat. No.: HY-D1005A22
CAS No.: 9003-11-6
Synonyms: PEG-PPG-PEG, 14600 (Average)
Poloxamer 338 F108 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 14600. Poloxamer 338 F108 reduces the aggregation of red blood cells, inhibits proliferation of human lymphocyte cell IIBR1. Poloxamer 338 F108 exhibits short-term and subchronic toxicity in rats .
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Cat. No.: HY-15582
CAS No.: 160800-57-7
Purity:  99.82%
Research Areas:  

Cancer

Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids .
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Cat. No.: HY-D1005A2
CAS No.: 9003-11-6
Synonyms: PEG-PPG-PEG, 1900 (Average)
Poloxamer 105 L35 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1900 Da. Poloxamer 105 L35 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .
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Cat. No.: HY-158712
Purity:  ≥98.0%
3'-ONH2-dATP sodium solution (100mM) is a 3'-O-blocked reversible terminator deoxynucleotide triphosphate. 3'-ONH2-dATP sodium solution (100mM) stops DNA polymerization after single-nucleotide addition to an initiator strand, and its 3'-ONH2 blocking group can be removed to restore a free 3'-OH for subsequent extension .
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Cat. No.: HY-D1005A8
CAS No.: 9003-11-6
Synonyms: PEG-PPG-PEG, 2000 (Average)
Poloxamer 181 L61 is a block polymer of polyethylene oxide and polypropylene oxide with an average molecular weight of 2000. Poloxamer has the ability to inhibit P-gp. Poloxamer 181 has antimicrobial activity and can inhibit Mycobacterium avium. Poloxamer 181 can form a thermally reversible hydrogel and is used as a food additive, and as an agent delivery carrier in cosmetics, pharmaceuticals and tissue engineering .
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Cat. No.: HY-140696E
CAS No.: 9004-74-4
Purity:  ≥98.0%
Synonyms: mPEG1000-Hydroxy; Polyethylene glycol monomethyl ether 1000
m-PEG1000-OH (mPEG1000-Hydroxy) is a monomethoxypolyethylene glycol and also a macroinitiator for organocatalytic ring-opening polymerization of aliphatic cyclic carbonate monomers. m-PEG1000-OH can participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles for active drug delivery .
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Cat. No.: HY-140697
CAS No.: 9004-74-4
Purity:  ≥98.0%
Synonyms: mPEG5000-Hydroxy; Polyethylene glycol monomethyl ether 5000
m-PEG5000-OH (mPEG5000-Hydroxy) is a monomethoxypolyethylene glycol and also a macroinitiator for organocatalytic ring-opening polymerization of aliphatic cyclic carbonate monomers. m-PEG1000-OH can participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles for active drug delivery .
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Cat. No.: HY-W105423
CAS No.: 38862-25-8
Synonyms: NHS-MA
Methacrylic acid N-hydroxysuccinimide ester (NHS-MA) is a polymer that serves as a monomer to prepare degradable amphiphilic block copolymer microparticles via RAFT polymerization for low pH-triggered drug delivery. Methacrylic acid N-hydroxysuccinimide ester is used for the synthesis of nanogels .
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