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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
cAMP concentrations
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "cAMP concentrations" in MCE Product Catalog:
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1 Cited Publications
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HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP .
Cat. No.: HY-N2452
CAS No.: 956103-79-0
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Cat. No.: HY-177122
CAS No.: 3034857-88-7
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Raxlaprazine etomoxil is a small molecule compound with dopamine D2 and D3 receptor modulating activity, which has potential application value in research related to mental illnesses. Raxlaprazine etomoxil exhibits high affinity for human recombinant D2L receptors, with an inhibition constant (Ki) of 1.95 nM. Raxlaprazine etomoxil effectively inhibits forskolin-stimulated cAMP accumulation, with an half maximal effective concentration (EC50) of 3.72 nM in functional activity experiments .
Cat. No.: HY-122622
CAS No.: 1655498-17-1
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PF-04471141 (hydrochloride) is a compound that regulates intracellular cAMP and cGMP concentrations. It is a PDE1 inhibitor and has different effects on different PDE enzymes in regulating intracellular signaling molecule concentrations and cell proliferation in vascular smooth muscle cells.
Cat. No.: HY-114990
CAS No.: 148714-88-9
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EMD 57439 is a selective PDE-III inhibitor. EMD 57439 does not significantly increase c-AMP concentration and has little effect on Ca(50) .
Cat. No.: HY-124381
CAS No.: 174008-52-7
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ML10375 is a compound that modulates 5-HT4 and 5-HT2 receptors, affects gap junction coupling in rat atrial myocytes, and regulates intracellular cAMP concentration and L-type calcium current.
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Cat. No.: HY-69172
CAS No.: 152814-89-6
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Cardiovascular Disease Neurological Disease Inflammation/Immunology
RS-25344 is a selective inhibitor of phosphodiesterase type IV (PDE4). RS-25344 increases intracellular cAMP (cyclic adenosine phosphate) concentration by inhibiting PDE4 activity. RS-25344 can be used in the study of inflammation, immune diseases, neurodegenerative diseases and cardiovascular diseases .
Cat. No.: HY-153542
CAS No.: 2234276-60-7
AP-C6 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 6.5. AP-C6 concentration-dependently inhibits human cGKII activity in vitro. AP-C6 potentiate cAMP signaling by PDE inhibition .
Cat. No.: HY-113513
CAS No.: 92008-51-0
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Cat. No.: HY-116755
CAS No.: 55837-29-1
Synonyms: CR 605
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Tiropramide (CR 605) is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide relaxes smooth muscle in rabbit isolated colon. Tiropramide can be used for the research of irritable colon and biliary dyskinesia .
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MRS2690 is a selective P2Y14 receptor agonist. MRS2690 inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 induces intracellular calcium mobilization, activates P38 and stimulates [ 35S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690can be used for ischemic heart disease .
Cat. No.: HY-116295A
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MRS2690 disodium is a selective P2Y14 receptor agonist. MRS2690 disodium inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 disodium induces intracellular calcium mobilization, activates P38 and stimulates [ 35S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690 disodium can be used for ischemic heart disease .
Cat. No.: HY-P0248F1
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Cat. No.: HY-43934
CAS No.: 53567-47-8
Synonyms: CR 605 hydrochloride
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Tiropramide (CR 605) hydrochloride is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide hydrochloride relaxes smooth muscle in rabbit isolated colon. Tiropramide hydrochloride can be used for the research of irritable colon and biliary dyskinesia .
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Cat. No.: HY-182774
CAS No.: 1092445-63-0
YU241279 is an orally active CXCR5 inhibitor. YU241279 inhibits CXCL13-mediated Gαq-dependent calcium influx and Gαi2-dependent cAMP reduction in CXCR5-expressing cells. YU241279 inhibits the proliferation of CXCR5-expressing lymphoma cells. YU241279 reduces tumor burden in the peripheral blood and bone marrow of mice implanted with lymphoma tissues. YU241279 is well tolerated during oral administration in mice, maintains stable plasma drug concentrations, and shows no metabolic changes. YU241279 can be used in the research of angioimmunoblastic T-cell lymphoma and Burkitt B-cell lymphoma .
Cat. No.: HY-183657
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GPR3 inverse agonist-1 is a GPR3 inverse agonist with low micromolar potency in conformational analysis. GPR3 inverse agonist-1 inhibits GPR3-dependent Gs activity in HEK293A cells with an EC50 of 250 nM, and exhibits an EC50 of 2 μM in cAMP assays. GPR3 inverse agonist-1 induces concentration-dependent changes in BRET signals in GPR3 conformational biosensors (EC50 = 5 μM), reduces basal Gs activity downstream of GPR3, and competes for binding sites with the GPR3 agonist DPI (HY-100965). GPR3 inverse agonist-1 can be used in research related to Alzheimer's disease .
Cat. No.: HY-183657A
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GPR3 inverse agonist-1 TFA is a GPR3 inverse agonist with low micromolar potency in conformational analysis. GPR3 inverse agonist-1 TFA inhibits GPR3-dependent Gs activity in HEK293A cells with an EC50 of 250 nM, and exhibits an EC50 of 2 μM in cAMP assays. GPR3 inverse agonist-1 TFA induces concentration-dependent BRET signal changes in GPR3 conformational biosensors (EC50 = 5 μM), reduces basal Gs activity downstream of GPR3, competes for binding sites with the GPR3 agonist DPI (HY-100965). GPR3 inverse agonist-1 TFA can be used in research related to Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
