1383539-73-8
1383539-73-8
Chemical Structure
HJC0197
- CAS No.: 1383539-73-8
- Formula:C19H21N3OS
- Molecular Weight:339.45
IUPAC Name: 4-cyclopentyl-2-((2,5-dimethylbenzyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
InChIKey: QLLWRTHDHRGHQZ-UHFFFAOYSA-N
SMILES: N#CC1=C(C2CCCC2)N=C(SCC3=CC(C)=CC=C3C)NC1=O
Biological Activity: HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HJC0197 | 99.62% | HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP. | ||||||||||||||||||||
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References
Keywords
