7219-59-2
Chemical Structure
Glu-Arg
- CAS No.: 7219-59-2
- Formula:C11H21N5O5
- Molecular Weight:303.32
IUPAC Name: (S)-4-amino-5-(((S)-1-carboxy-4-guanidinobutyl)amino)-5-oxopentanoic acid
InChIKey: MPZWMIIOPAPAKE-BQBZGAKWSA-N
SMILES: [C@H](NC([C@H](CCC(O)=O)N)=O)(CCCNC(=N)N)C(O)=O
Biological Activity: Glu-Arg is a dipeptide linked by L-glutamic acid and L-arginine. Glu-Arg contributes to the construction of the hydrophobic network and maintenance of stability of mouse cAMP-dependent protein kinase; it acts as a core hub connecting the activation segment and the GHI subdomain in eukaryotic protein kinases, and promotes signal transmission between elements and within enzymes. As a salt bridge, Glu-Arg regulates the formation and unfolding rates of α-helices, and its optimized spatial conformation is conducive to the stability and folding rate of α-helices. Glu-Arg induces concentration-dependent intracellular calcium changes in cultured human fungiform taste bud cells[1][2][3].
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Glu-Arg | Glu-Arg is a dipeptide linked by L-glutamic acid and L-arginine. Glu-Arg contributes to the construction of the hydrophobic network and maintenance of stability of mouse cAMP-dependent protein kinase; it acts as a core hub connecting the activation segment and the GHI subdomain in eukaryotic protein kinases, and promotes signal transmission between elements and within enzymes. As a salt bridge, Glu-Arg regulates the formation and unfolding rates of α-helices, and its optimized spatial conformation is conducive to the stability and folding rate of α-helices. Glu-Arg induces concentration-dependent intracellular calcium changes in cultured human fungiform taste bud cells. | |||||||||||||||||||||
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References
- [1]. Yang J, et al. A Conserved Glu–Arg Salt Bridge Connects Coevolved Motifs That Define the Eukaryotic Protein Kinase Fold. Journal of Molecular Biology, 2012, 415(4): 666-679.
- [2]. Meuzelaar H, et al. Influence of Glu/Arg, Asp/Arg, and Glu/Lys Salt Bridges on α-Helical Stability and Folding Kinetics. Biophysical journal. 2016 Jun 07;110(11):2328-2341. [Content Brief]
- [3]. Xu JJ, et al. Arginyl dipeptides increase the frequency of NaCl-elicited responses via epithelial sodium channel alpha and delta subunits in cultured human fungiform taste papillae cells. Scientific reports. 2017 Aug 08;7(1):7483. [Content Brief]
