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Results for "

cereblon-based

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) BCL6 (1) Bcr-Abl (1) Casein Kinase (1) Caspase (1) CD20 (1) CDK (1) E3 Ligase Ligand-Linker Conjugates (1) EGFR (1) ERK (3) Histone Methyltransferase (1) IKZF Family (2) IRAK (4) Ligands for E3 Ligase (2) MDM-2/p53 (1) Molecular Glues (11) PARP (1) PROTACs (16) Ras (5) RIP kinase (1) SOS1 (4) Src (2)
By Research Areas:	Cancer (29) Infection (1) Inflammation/Immunology (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-159646

BMS-986397	Molecular Glues Ligands for E3 Ligase Casein Kinase Apoptosis MDM-2/p53	Inflammation/Immunology Cancer
BMS-986397 is a potent, selective, and orally active cereblon-based molecular glue degrader of casein kinase 1α (CK1α). BMS-986397 induces apoptosis and cell cycle arrest in acute myeloid leukemia (AML) cells. BMS-986397 is a promising agent for the investigation of AML and high-risk myelodysplastic syndromes (HR-MDS) .

HY-172736

BMS-986458	PROTACs BCL6 CD20	Cancer
BMS-986458 is a highly selective, orally active cereblon-based BCL6 PROTAC degrader and antitumor agent. BMS-986458 selectively degrades BCL6 by binding cereblon to the BTB domain of BCL6, thereby regulating the cell cycle, antiproliferative and interferon signaling pathways, and upregulating the expression and distribution of CD20. BMS-986458 modulates the phenotype of follicular helper T cells and reduces circulating tumor DNA levels. The combination of BMS-986458 with CD20xCD3 bispecific antibody also enhances the efficiency of T cell tumor infiltration and expansion. BMS-986458 induces regression of BCL6-positive tumors and prolongs survival, and it is suitable for research related to B-cell non-Hodgkin lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, and relapsed/refractory lymphoma .

HY-139186

PROTAC KRAS G12C degrader-1	PROTACs Ras	Cancer
PROTAC KRAS G12C degrader-1 is a *Cereblon*-based KRAS ^G12C PROTAC degrader. PROTAC KRAS G12C degrader-1 induces CRBN/ KRAS ^G12C dimerization and degrades GFP- KRAS ^G12C in reporter cells .

HY-175451

MRT-10350	Molecular Glues Src	Infection Cancer
MRT-10350 (Compound 2) is a cereblon-based HCK molecular glue degrader. MRT-10350 can be used for cancers like chronic myeloid leukemia and HIV-1 infections research .

HY-176444A

(R)-CDK2 degrader 6	Molecular Glues CDK	Cancer
(R)-CDK2 degrader 6 is the R-enantiomer of CDK2 degrader 6 (HY-176444), a *cereblon*-based molecular glue degrader of CDK2 with a DC₅₀ of 27 nM. (R)-CDK2 degrader 6 induces ubiquitination and proteasomal degradation of CDK2 by bridging cereblon and CDK2. (R)-CDK2 degrader 6 is applicable for cancer research .

HY-129966

PROTAC IRAK4 degrader-1 1 Publications Verification	PROTACs IRAK	Cancer
PROTAC IRAK4 degrader-1 (compound I-210) is a Cereblon-based IRAK4 PROTAC. PROTAC IRAK4 degrader-1 is composed of IRAK4 ligand (red part) PROTAC IRAK4 ligand-1 (HY-129967), E3 ligase ligand (blue part) Pomalidomide (HY-10984), and PROTAC linker (black part) AM-Imidazole-PA-Boc (HY-129968) .

HY-161574

LLC0424	PROTACs Histone Methyltransferase	Cancer
LLC0424 is a potent and selective *cereblon*-based PROTAC nuclear receptor-binding SET domain-containing 2 (NSD2) degrader. LLC0424 effectively degraded NSD2 with a DC₅₀ of 20 nM in RPMI-8402 cells. LLC0424 selectively induces NSD2 degradation in a cereblon- and proteasome-dependent fashion. (Blue: CRBN ligand (HY-14658), Black: linker (HY-40002); Pink: NSD2 inhibitor (HY-161575)) .

HY-168669

PROTAC K-Ras Degrader-5	PROTACs Ras Caspase ERK	Cancer
PROTAC K-Ras Degrader-5 is a cereblon-based K-Ras PROTAC degrader with a DC₅₀ of <100 nM for KRAS ^G12D. PROTAC K-Ras Degrader-5 recruits KRAS ^G12D to the cereblon E3 ubiquitin ligase complex for ubiquitination and subsequent proteasomal degradation. PROTAC K-Ras Degrader-5 suppresses pERK levels downstream of KRAS ^G12D degradation in cancer cells. PROTAC K-Ras Degrader-5 reduces proliferation of cancer cells. PROTAC K-Ras Degrader-5 induces caspase 3/7 activity and cPARP, markers of apoptosis, in pancreatic cancer spheroids and tumors. PROTAC K-Ras Degrader-5 can be used for the research of pancreatic cancer and colorectal cancer .

HY-111870

PROTAC RIPK degrader-6	PROTACs RIP kinase	Cancer
PROTAC RIPK degrader-6 (example 1) is a *Cereblon*-based PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder .

HY-159647A

(S,S)-PLX-4545	Molecular Glues IKZF Family	Cancer
(S,S)-PLX-4545 (Compound I) is an orally active and cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios). (S,S)-PLX-4545 can be used for the study of IKZF2-mediated diseases or disorders, such as proliferative diseases or disorders and/or cancer .

HY-159647B

(1S,2S,3R)-PLX-4545	Molecular Glues IKZF Family	Cancer
(1S,2S,3R)-PLX-4545 is the (1S,2S,3R) enantiomer of PLX-4545 (HY-159647). PLX-4545 is an orally active and selective cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios). PLX-4545 can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses .

HY-161235

BTX-7312	SOS1 Molecular Glues Ras	Cancer
BTX-7312 is a cereblon-based SOS1 bifunctional degrader and a molecular glue. BTX-7312 reduces downstream signaling markers pERK and pS6 and shows antiproliferative activity in various KRAS-mutated cells .

HY-145615

Pomalidomide-C12-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1 (HY-139186). PROTAC KRAS G12C degrader-1 is a *Cereblon*-based KRAS ^G12C degrader .

HY-122653A

CCT367766 formic	PROTACs	Cancer
CCT367766 formic is a potent and the third generation heterobifunctional and *Cereblon*-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC₅₀ value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with K_d values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein .

HY-161233A

BTX-6654 formate	PROTACs SOS1 ERK	Cancer
BTX-6654 formate is a target-dependent and -specific cereblon-based bifunctional SOS1 PROTAC degrader. BTX-6654 formate reduces downstream signaling markers pERK and pS6, and displays antiproliferative activity in cells harboring various KRAS mutations .

HY-161233

BTX-6654	PROTACs SOS1 ERK	Cancer
BTX-6654 is a target-dependent and -specific cereblon-based bifunctional SOS1 PROTAC degrader. BTX-6654 reduces downstream signaling markers pERK and pS6, and displays antiproliferative activity in cells harboring various KRAS mutations .

HY-141481

DP-C-4	PROTACs EGFR PARP	Cancer
DP-C-4 is a *Cereblon*-based dual PROTAC for simultaneous degradation of EGFR and PARP .

HY-139316

PROTAC IRAK4 degrader-5	IRAK PROTACs	Cancer
PROTAC IRAK4 degrader-5 is a *Cereblon*-based IRAK4 degrader extracted from patent US20190192668A1, compound I-171 .

HY-168678

PROTAC K-Ras Degrader-6	PROTACs Ras	Cancer
PROTAC K-Ras Degrader-6 (compound 102) is a potent cereblon-based KRAS PROTAC degrader, with a DC50 of ≤100 nM. PROTAC K-Ras Degrader-6 shows anticancer effects .

HY-139315

PROTAC IRAK4 degrader-4	PROTACs IRAK	Cancer
PROTAC IRAK4 degrader-4 is a *Cereblon*-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127 .

HY-175437

MRT-7612	Molecular Glues Src Bcr-Abl	Inflammation/Immunology Cancer
MRT-7612 (Compound 4) is a cereblon-based tyrosine kinases molecular glue degrader. MRT-7612 significantly induces HCK and LYN degradation, with week efficacy on LCK. MRT-7612 can be used for cancers like chronic myeloid leukemia, autoimmune and chronic inflammatory diseases research .

HY-139317

PROTAC IRAK4 degrader-6	PROTACs IRAK	Cancer
PROTAC IRAK4 degrader-6 is a *Cereblon*-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-172 .

HY-159610

GSPT1 degrader-10	Molecular Glues	Cancer
GSPT1 degrader-10 (compound A) is a cereblon-based molecular glue degrader of GSPT1 with more than 95% degradation. GSPT1 degrader-8 inhibits cell viability in HL-60 cells with an IC₅₀ of 10 nM .

HY-159609

GSPT1 degrader-9	Molecular Glues	Cancer
GSPT1 degrader-9 (Compound F) is a cereblon-based molecular glue degrader for G1 to S phase transition protein 1 (GSPT1) that degrades GSPT1 with a rate of 95% (1 μM) GSPT1 and 86% (0.1 μM). GSPT1 degrader-9 inhibits the cell viability of HL-60 with an IC₅₀ of 9.2 nM .

HY-177765

GSPT1 degrader-16	Molecular Glues	Cancer
GSPT1 degrader-16 (Compound Lib-B-18J) is a potent and selective cereblon-based molecular glue degrader that targets G1 to S phase transition 1 (GSPT1). GSPT1 degrader-16 shows inhibitory effect to RS4;11, Molt4, and MM.1S cells with IC₅₀ values of 0.002, 0.26 and 0.37 μM. GSPT1 degrader-16 can be used for the research of cancer, such as acute lymphoblastic leukemi .

HY-168637

SIAIS562055	SOS1 PROTACs Ras	Cancer
SIAIS562055 is a potent cereblon-based SOS1 PROTAC with a K_d of 95.9 nM. SIAIS562055 exhibits sustained degradation of SOS1 and inhibition of downstream ERK pathways. SIAIS562055 effectively blocked the binding of KRAS ^G12C or KRAS ^G12D to SOS1, with the IC₅₀ values of 95.7 nM and 134.5 nM, respectively. SIAIS562055 exhibits potent anticancer activity. (Pink: SOS1 ligand (HY-168638); Black: linker (HY-W539874); Blue: E3 ligase ligand (HY-W076696)) .

HY-177766

GSPT1 degrader-17	Molecular Glues Apoptosis	Cancer
GSPT1 degrader-17 (Compound 9q) is a potent and selective cereblon-based molecular glue degrader that targets G1 to S phase transition 1 (GSPT1). GSPT1 degrader-17 degrades GSPT1 in U937 cells with a DC₅₀ of 35 nM and Dmax of 81.65%. GSPT1 degrader-17 has a strong inhibitory effect on U937, MOLT-4 and MV4-11 cells with IC₅₀ values of 0.019, 0.006 and 0.027 μM. GSPT1 degrader-17 can induce cells apoptosis and G0/G1 phase arrest. GSPT1 degrader-17 can be used for the research of cancer, such as acute myeloid leukemia .

HY-122653

CCT367766	PROTACs	Cancer
CCT367766 is a potent and the third generation heterobifunctional and *Cereblon*-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC₅₀ value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with K_d values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein .

HY-163210

Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride	Ligands for E3 Ligase	Cancer
Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride (ZJT1) is an E3 ubiquitin ligase cereblon based on Pomalidomide (HY-10984) (CRBN) ligand for recruitment of cereblon protein. Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride can be linked to protein ligand by linker to form PROTAC .

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