3083777-50-5
Chemical Structure
(R)-CDK2 degrader 6
- CAS No.: 3083777-50-5
- Formula:C23H22F5N5O3
- Molecular Weight:511.44
IUPAC Name: (R)-3-(2,6-difluoro-4-((2R,3S)-2-methyl-3-((5-(3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)-1,3,4-oxadiazol-2-yl)amino)azetidin-1-yl)phenyl)piperidine-2,6-dione
InChIKey: DYUMYEGVQNMNAQ-HXDJBORHSA-N
SMILES: FC(F)(C12CC(C2)(C3=NN=C(N[C@@H]4[C@H](N(C5=CC(F)=C([C@@H]6C(NC(CC6)=O)=O)C(F)=C5)C4)C)O3)C1)F
Biological Activity: (R)-CDK2 degrader 6 is the R-enantiomer of CDK2 degrader 6 (HY-176444), a cereblon-based molecular glue degrader of CDK2 with a DC50 of 27 nM. (R)-CDK2 degrader 6 induces ubiquitination and proteasomal degradation of CDK2 by bridging cereblon and CDK2. (R)-CDK2 degrader 6 is applicable for cancer research[1].
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(R)-CDK2 degrader 6 | 99.55% | (R)-CDK2 degrader 6 is the R-enantiomer of CDK2 degrader 6 (HY-176444), a cereblon-based molecular glue degrader of CDK2 with a DC50 of 27 nM. (R)-CDK2 degrader 6 induces ubiquitination and proteasomal degradation of CDK2 by bridging cereblon and CDK2. (R)-CDK2 degrader 6 is applicable for cancer research. | ||||||||||||||||||||
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Keywords
