2892066-42-9

(1S,2S,3R)-PLX-4545 Chemical Structure
2892066-42-9

Chemical Structure

(1S,2S,3R)-PLX-4545

  • CAS No.: 2892066-42-9
  • Formula:C28H31N3O4
  • Molecular Weight:473.56

SMILES: O=C([C@H](N(CC1=C2C=CC(O[C@@H]3[C@@H](N4CC(C5=CC=CC=C5)C4)CCCC3)=C1)C2=O)CC6)NC6=O

Biological Activity: (1S,2S,3R)-PLX-4545 is the (1S,2S,3R) enantiomer of PLX-4545 (HY-159647). PLX-4545 is an orally active and selective cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios). PLX-4545 can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses[1].

Cat. No. Product Name Purity Description Pricing
HY-159647B 		(1S,2S,3R)-PLX-4545 91.78% (1S,2S,3R)-PLX-4545 is the (1S,2S,3R) enantiomer of PLX-4545 (HY-159647). PLX-4545 is an orally active and selective cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios). PLX-4545 can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses.
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