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curcumin derivative

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By Targets:	Drug Derivative (2) Amyloid-β (2) Apoptosis (6) Autophagy (2) Bacterial (1) Bcl-2 Family (1) Caspase (2) COX (1) CTLA-4 (1) Epigenetic Reader Domain (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) Isotope-Labeled Compounds (2) JNK (1) Keap1-Nrf2 (2) MAP4K (1) MMP (1) mTOR (2) NF-κB (4) NO Synthase (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) TGF-beta/Smad (1) TrxR (1)
By Research Areas:	Cancer (7) Inflammation/Immunology (3) Neurological Disease (3)

By Targets:

Drug Derivative (2)

Amyloid-β (2)

Apoptosis (6)

Autophagy (2)

Bacterial (1)

Bcl-2 Family (1)

Caspase (2)

COX (1)

CTLA-4 (1)

Epigenetic Reader Domain (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Acetyltransferase (1)

Isotope-Labeled Compounds (2)

JNK (1)

Keap1-Nrf2 (2)

MAP4K (1)

MMP (1)

mTOR (2)

NF-κB (4)

NO Synthase (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (2)

TGF-beta/Smad (1)

TrxR (1)

By Research Areas:

Cancer (7)

Inflammation/Immunology (3)

Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Derivative

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0007

(E,E)-Bisdemethoxycurcumin 4 Publications Verification (E,E)-curcumin III; (E,E)-Didemethoxycurcumin	Apoptosis Autophagy	Cancer
(E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities .

HY-100977

Dimethoxycurcumin DiMC; CHC 004; Di-O-methylcurcumin	NO Synthase NF-κB	Inflammation/Immunology
Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities .

HY-137315

TML-6	Amyloid-β NF-κB mTOR Keap1-Nrf2	Neurological Disease
TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research .

HY-179228

AN02	CTLA-4 TGF-beta/Smad	Cancer
AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer .

HY-N0894R

Octahydrocurcumin (Standard) Hexahydrobisdemethoxycurcumin (Standard)	Reference Standards Apoptosis COX NF-κB MAP4K	Inflammation/Immunology Cancer
Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is a hydrogenated derivative of curcumin and a metabolite of curcumin. Octahydrocurcumin is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively .

HY-N0007R

(E,E)-Bisdemethoxycurcumin (Standard) (E,E)-curcumin III (Standard); (E,E)-Didemethoxycurcumin (Standard)	Reference Standards Apoptosis Autophagy	Cancer
(E,E)-Bisdemethoxycurcumin (Standard) is the analytical standard of (E,E)-Bisdemethoxycurcumin. This product is intended for research and analytical applications. (E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities .

HY-137315S

TML-6-d3	Isotope-Labeled Compounds Amyloid-β Keap1-Nrf2 mTOR NF-κB	Neurological Disease
TML-6-d₃ is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-

HY-15668

ST09	MMP Bcl-2 Family Caspase Apoptosis Drug Derivative	Cancer
ST09 is an efficient and low toxicity Curcumin (HY-N0005) derivative. ST09 significantly inhibits cell migration and downregulates the expression of MMP1, MMP2, and Vimentin. ST09 has strong cytotoxicity to breast cancer cells, such as MDA-MB-231, MCF7 and T47D cells. ST09 induces cell apoptosis by upregulating Bax and cleaved caspase-3/9. ST09 can be used in the research of cancer such as breast cancer .

HY-151342

Ser@TPP@CUR	Drug Derivative	Others
Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .

HY-120914

TrxR1-IN-B19 GO-Y015	TrxR Apoptosis	Cancer
TrxR1-IN-B19 (GO-Y015) (Compound B19) is a Curcumin (HY-N0005) derivative and colvalent TrxR1 inhibitor. TrxR1-IN-B19 inhibits TrxR1 enzyme activity to elevate oxidative stress, and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis .

HY-N12669

Curcumin monoglucoside	Bacterial Reactive Oxygen Species (ROS) Apoptosis JNK Caspase	Neurological Disease
Curcumin monoglucoside is a flavonoid derivative possessing antioxidant, anti-apoptotic, neuroprotective effects, and antibacterial activity. Curcumin monoglucoside can be used in research on Parkinson's disease.

HY-100977S

Dimethoxycurcumin-d6 DiMC-d₆; CHC 004-d₆; Di-O-methylcurcumin-d₆	Isotope-Labeled Compounds	Inflammation/Immunology
Dimethoxycurcumin-d₆ is the deuterium labeled Dimethoxycurcumin (HY-100977). Dimethoxycurcumin is a derivative of Curcumin that has anti-inflammatory and antioxidant activities .

HY-139804

CTK7A	Epigenetic Reader Domain Histone Acetyltransferase HIF/HIF Prolyl-Hydroxylase	Cancer
CTK7A is a curcumin derivative with anticancer activity by inhibiting the HAT activity of p300 and reducing the autoacetylation of p300, thereby affecting its interaction with HIF-1α. The inhibition of CTK7A leads to decreased HIF-1α accumulation and activity, which can be used for cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0007

(E,E)-Bisdemethoxycurcumin 4 Publications Verification (E,E)-curcumin III; (E,E)-Didemethoxycurcumin	Zingiber officinale Roscoe Structural Classification Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification Zingiberaceae Cancer	Apoptosis Autophagy
(E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities .

HY-N0894R

Octahydrocurcumin (Standard) Hexahydrobisdemethoxycurcumin (Standard)	Structural Classification Phenols Polyphenols Plants Curcuma longa Source Classification Zingiberaceae	Reference Standards Apoptosis COX NF-κB MAP4K
Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is a hydrogenated derivative of curcumin and a metabolite of curcumin. Octahydrocurcumin is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively .

HY-N0007R

(E,E)-Bisdemethoxycurcumin (Standard) (E,E)-curcumin III (Standard); (E,E)-Didemethoxycurcumin (Standard)	Zingiber officinale Roscoe Structural Classification Phenols Polyphenols Plants Source Classification Zingiberaceae	Reference Standards Apoptosis Autophagy
(E,E)-Bisdemethoxycurcumin (Standard) is the analytical standard of (E,E)-Bisdemethoxycurcumin. This product is intended for research and analytical applications. (E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities .

HY-N12669

Curcumin monoglucoside	Apocynaceae Plants Saccharides Monosaccharides Catharanthus roseus (L.) G. Don Source Classification	Bacterial Reactive Oxygen Species (ROS) Apoptosis JNK Caspase
Curcumin monoglucoside is a flavonoid derivative possessing antioxidant, anti-apoptotic, neuroprotective effects, and antibacterial activity. Curcumin monoglucoside can be used in research on Parkinson's disease.

Cat. No.	Product Name	Chemical Structure

HY-137315S

TML-6-d3
TML-6-d₃ is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-

HY-100977S

Dimethoxycurcumin-d6
Dimethoxycurcumin-d₆ is the deuterium labeled Dimethoxycurcumin (HY-100977). Dimethoxycurcumin is a derivative of Curcumin that has anti-inflammatory and antioxidant activities .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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curcumin derivative

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Isotope-Labeled Compounds

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