Ser@TPP@CUR

Cat. No.: HY-151342: FAQs
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Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .

For research use only. We do not sell to patients.

Ser@TPP@CUR Chemical Structure

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Description

In Vitro

Ser@TPP@CUR (7.16 μg/mL; 24 h) effectively reduces ROS level in inflammatory HK-2 cells^[1].
Ser@TPP@CUR (3 μg/mL; 24 h) effects cell viability and inhibits expression levels of cytosolic cytochrome c, cleaved caspase-3, and cleaved caspase-9 of LPS-induced HK-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	LPS-induced HK-2 cell lines
Concentration:	3 μg/mL
Incubation Time:	24 hours
Result:	Significantly improved cell viability of LPS-induced HK-2 cells.

In Vivo

Ser@TPP@CUR (4 mg/kg; i.v. once) shows a better distribution in renal tissues via KIM-1-receptor-mediated endocytosis in renal tubule epithelial cells and restores renal function of AKI mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	AKI mice^[1]
Dosage:	4 mg/kg
Administration:	Intravenous injection; 4 mg/kg once
Result:	Showed a better distributionin in renal tissues than CUR at 2 hours after injection and restored renal function of AKI mice by alleviated Scr and BUN levels.

Molecular Weight

880.76

Formula

C₄₇H₄₇BrNO₉P

SMILES

O=C(OC1=CC=C(C=C1OC)/C=C/C(CC(/C=C/C2=CC(OC)=C(OC(C(N)CO)=O)C=C2)=O)=O)CCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yan X, et al. A Stepwise Targeting Curcumin Derivative, Ser@TPP@CUR, for Acute Kidney Injury. ACS Med Chem Lett. 2022 Mar 8;13(4):554-559. [Content Brief]

Ser@TPP@CUR Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ser@TPP@CUROtherscurcumin derivativeKIM-1renal tubular epithelial cellmitochondriamoleculeTPPacute kidney injuryInhibitorinhibitorinhibit

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