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[email protected]@CUR is a Curcumin (HY-N0005) derivative. [email protected]@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. [email protected]@CUR can be used for the research of AKI .

For research use only. We do not sell to patients.

Ser@TPP@CUR Chemical Structure

[email protected]@CUR Chemical Structure

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Description

[email protected]@CUR is a Curcumin (HY-N0005) derivative. [email protected]@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. [email protected]@CUR can be used for the research of AKI[1] .

In Vitro

[email protected]@CUR (7.16 μg/mL; 24 h) effectively reduces ROS level in inflammatory HK-2 cells[1].
[email protected]@CUR (3 μg/mL; 24 h) effects cell viability and inhibits expression levels of cytosolic cytochrome c, cleaved caspase-3, and cleaved caspase-9 of LPS-induced HK-2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: LPS-induced HK-2 cell lines
Concentration: 3 μg/mL
Incubation Time: 24 hours
Result: Significantly improved cell viability of LPS-induced HK-2 cells.
In Vivo

[email protected]@CUR (4 mg/kg; i.v. once) shows a better distribution in renal tissues via KIM-1-receptor-mediated endocytosis in renal tubule epithelial cells and restores renal function of AKI mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AKI mice[1]
Dosage: 4 mg/kg
Administration: Intravenous injection; 4 mg/kg once
Result: Showed a better distributionin in renal tissues than CUR at 2 hours after injection and restored renal function of AKI mice by alleviated Scr and BUN levels.
Molecular Weight

880.76

Formula

C47H47BrNO9P

SMILES

O=C(OC1=CC=C(C=C1OC)/C=C/C(CC(/C=C/C2=CC(OC)=C(OC(C(N)CO)=O)C=C2)=O)=O)CCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Product Name:
[email protected]@CUR
Cat. No.:
HY-151342
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