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Cat. No.: HY-151342

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Ser@TPP@CUR

Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .

For research use only. We do not sell to patients.

CAS No.: 3032193-12-4
Formula: C₄₇H₄₇BrNO₉P
Molecular Weight:880.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Ser@TPP@CUR Chemical Structure

CAS No.: 3032193-12-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Ser@TPP@CUR (7.16 μg/mL; 24 h) effectively reduces ROS level in inflammatory HK-2 cells^[1].
Ser@TPP@CUR (3 μg/mL; 24 h) effects cell viability and inhibits expression levels of cytosolic cytochrome c, cleaved caspase-3, and cleaved caspase-9 of LPS-induced HK-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

LPS-induced HK-2 cell lines
Concentration:

3 μg/mL
Incubation Time:

24 hours
Result:

Significantly improved cell viability of LPS-induced HK-2 cells.

In Vivo

Ser@TPP@CUR (4 mg/kg; i.v. once) shows a better distribution in renal tissues via KIM-1-receptor-mediated endocytosis in renal tubule epithelial cells and restores renal function of AKI mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

AKI mice^[1]
Dosage:

4 mg/kg
Administration:

Intravenous injection; 4 mg/kg once
Result:

Showed a better distributionin in renal tissues than CUR at 2 hours after injection and restored renal function of AKI mice by alleviated Scr and BUN levels.

Chemical Information

CAS No. 3032193-12-4
Molecular Weight 880.76
Formula C₄₇H₄₇BrNO₉P
SMILES

COC(C=C1/C=C/C(CC(/C=C/C2=CC(OC)=C(OC(CCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)C=C2)=O)=O)=C(C=C1)OC([C@@H](N)CO)=O.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yan X, et al. A Stepwise Targeting Curcumin Derivative, Ser@TPP@CUR, for Acute Kidney Injury. ACS Med Chem Lett. 2022 Mar 8;13(4):554-559. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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