36062-07-4
Chemical Structure
Octahydrocurcumin
Synonym(s): Hexahydrobisdemethoxycurcumin
- CAS No.: 36062-07-4
- Formula:C21H28O6
- Molecular Weight:376.44
IUPAC Name: 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-diol
InChIKey: OELMAFBLFOKZJD-UHFFFAOYSA-N
SMILES: OC(CC(O)CCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2
Biological Activity: Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively[1][2].
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Octahydrocurcumin | 99.25% | Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively. | ||||||||||||||||||||
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Octahydrocurcumin (Standard) | ≥98% | Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is a hydrogenated derivative of curcumin and a metabolite of curcumin. Octahydrocurcumin is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively. | ||||||||||||||||||||
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References
- [1]. Zhang Z , et al. Octahydrocurcumin, a final hydrogenated metabolite of curcumin, possesses superior anti-tumor activity through induction of cellular apoptosis. Food Funct. 2018;9(4):2005-2014. [Content Brief]
- [2]. Zhang ZB, et al. Curcumin's Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway. Front Pharmacol. 2018;9:1181. Published 2018 Oct 17. [Content Brief]
