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Cat. No.: HY-N15613

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α-Synuclein inhibitor 14

α-Synuclein inhibitor 14 (Compound 3) is a diarylheptanoid that can be isolated from Alpinia officinarum. α-Synuclein inhibitor 14 can inhibit the aggregation of α-synuclein, with an inhibition rate of 72.4% at a concentration of 10 μM. α-Synuclein inhibitor 14 can be used in the research of neurodegenerative diseases such as Parkinson's disease.

For research use only. We do not sell to patients.

CAS No.: 408324-13-0
Formula: C₂₀H₂₆O₆
Molecular Weight:362.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

α-Synuclein inhibitor 14 Chemical Structure

CAS No.: 408324-13-0

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Classifications
Bioz

Biological Activity

Description

All α-synuclein Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	89.66 μM Compound: 6	Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 23707257]
HL-60	IC₅₀	4.1 μg/mL Compound: 7a	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 11908966]
RAW264.7	IC₅₀	25.79 μM Compound: 12	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction based spectrophotometry Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction based spectrophotometry	[PMID: 21807513]

Chemical Information

CAS No. 408324-13-0
Molecular Weight 362.42
Formula C₂₀H₂₆O₆
SMILES

OC(C=C1CC[C@@H](O)C[C@H](O)CCC2=CC(OC)=C(C=C2)O)=C(C=C1)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fu G, et al. Diarylheptanoids from Rhizomes of Alpinia officinarum Inhibit Aggregation of α-Synuclein. J Agric Food Chem. 2017 Aug 9;65(31):6608-6614. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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α-Synuclein inhibitor 14

All α-synuclein Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

α-Synuclein inhibitor 14 Related Classifications

HY-N15613 Related Classifications