Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica

  • Bioorg Med Chem Lett. 2013 Jul 1;23(13):3806-9. doi: 10.1016/j.bmcl.2013.04.073.
Kyeong Wan Woo  1 ,  Eunjung Moon ,  Oh Wook Kwon ,  Sung Ok Lee ,  Sun Yeou Kim ,  Sang Zin Choi ,  Mi Won Son ,  Kang Ro Lee
Affiliations
  • 1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Suwon, Gyeonggi-do 440-746, Republic of Korea.
PMID: 23707257 DOI: 10.1016/j.bmcl.2013.04.073
Abstract

In a continuing search for bioactive constituents from Dioscoreaceae medicinal Plants, two new cyclic diarylheptanoids, diosniponol A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of Dioscorea nipponica. The structures of these new compounds were determined by spectroscopic analyses, including extensive two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and optical rotation. All isolated compounds 1-12 were evaluated for their effects on nitric oxide (NO) production in murine microglia cell line BV-2. Compounds 8 and 11 showed potent inhibitory activities on NO production (IC50 13.36 and 14.36 μM, respectively) without cell toxicity in lipopolysaccharide-activated BV-2 cells.