Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
94 Results for "
deubiquitinating
" in MedChemExpress (MCE) Product Catalog:
Products (94)
94 Results for "deubiquitinating" in MCE Product Catalog:
15
15 Publications Verification
Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects .
13
13 Cited Publications
Synonyms: NSC 687852
Target:
Forschungsgebiete:
b-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14.
7
7 Cited Publications
Target:
Forschungsgebiete:
GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20. GSK2643943A has affinity with an IC50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC) .
7
7 Cited Publications
Art. -Nr.: HY-50737
CAS. Nr.: 924296-17-3
Target:
Forschungsgebiete:
Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
DUB-IN-3 (compound 22c) is a potent and selective inhibitor of the deubiquitinating enzyme USP8 with an IC50 value of 0.56 μM. DUB-IN-3 is promising for research of cancer, neurodegenerative diseases, inflammation, viral infection and cardiovascular disease .
4
4 Cited Publications
Target:
Forschungsgebiete:
BAY-805, a chemical probe, is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes .
3
3 Cited Publications
Target:
Forschungsgebiete:
CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 (IC50=~20 nM), with high selectivity over other DUB family members (1-100 μM). CMPD-39 inhibits the deubiquitinating activity of USP30, enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP; thus, CMPD-39 promotes phosphoubuitin accumulation, thereby accelerating mitochondrial autophagy (mitophagy) and peroxisomal autophagy (pexophagy). CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson's disease patients .
3
3 Cited Publications
Target:
Forschungsgebiete:
USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers.
1
1
1 Cited Publications
Art. -Nr.: HY-P702063
Reinheit: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: USP11; Ubiquitin carboxyl-terminal hydrolase 11; deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11
Species:
Source:
1
1 Cited Publications
Art. -Nr.: HY-P701447
Reinheit: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: USP28; Ubiquitin carboxyl-terminal hydrolase 28; deubiquitinating enzyme 28; Ubiquitin thioesterase 28; Ubiquitin-specific-processing protease 28
Species:
Source:
1
1 Cited Publications
Art. -Nr.: HY-P701411
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP15; Ubiquitin carboxyl-terminal hydrolase 15; deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15; Unph-2; Unph4
Species:
Source:
1
1 Cited Publications
Art. -Nr.: HY-P701450
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP30; Ubiquitin carboxyl-terminal hydrolase 30; deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30
Species:
Source:
1
1 Cited Publications
Art. -Nr.: HY-P701431
Reinheit: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: USP9X; Probable ubiquitin carboxyl-terminal hydrolase FAF-X; deubiquitinating enzyme FAF-X; Fat facets in mammals; hFAM; Fat facets protein-related; X-linked; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9; X chromosome; Ubiquitin-specific-processing protease FAF-X
Art. -Nr.: HY-D0843S
CAS. Nr.: 360768-37-2
Synonyms: NEM-d5
Art. -Nr.: HY-176426
Target:
Forschungsgebiete:
Subquinocin is a tumor suppressor CYLD inhibitor that inhibits USP family deubiquitinases (DUBs) activity of CYLD with an IC50 of 30 μM. Subquinocin enhances the activation of NF-κB and IFN pathways by inhibiting CYLD. Subquinocin promotes RIG-I-mediated activation of IRF3/IRF7 in the interferon pathway. Subquinocin can be used for the research of cancer and neurodegenerative diseases .
Target:
Forschungsgebiete:
RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells .
Art. -Nr.: HY-178124
Target:
Forschungsgebiete:
Huib32 is a potent small-molecule inhibitor of USP32 (IC50 = 21.2 nM), exhibiting high selectivity over other closely related deubiquitinating enzymes (DUBs), such as USP8/10/16, UCHL1 and OTUB2. Huib32 reversibly inhibits USP32 by covalently binding to the active site Cys743, which enhances substrate ubiquitination, alters endosomal morphology, and mimics USP32 depletion. Huib32 can be used for breast, ovarian, and lung cancer and Alzheimer's and Parkinson’s diseases research .
Art. -Nr.: HY-P10714
CAS. Nr.: 2396736-46-0
Target:
Forschungsgebiete:
Art. -Nr.: HY-141659A
Target:
Forschungsgebiete:
(R)-CMPD-39 is the R enantiomer of CMPD-39 ( HY-141659 ). CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 (IC50 =~20 nM), with high selectivity over other DUB family members (1-100 μM). CMPD-39 inhibits the deubiquitinating activity of USP30, enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP; thus, CMPD-39 promotes phosphoubuitin accumulation, thereby accelerating mitochondrial autophagy (mitophagy) and peroxisomal autophagy (pexophagy). CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson's disease patients .
Art. -Nr.: HY-124739
CAS. Nr.: 1426544-54-8
Target:
Forschungsgebiete:
HBX 28258 is a selective USP7 inhibitor, with an IC50 of 22.6 μM. HBX 28258 can covalently binds to Cys223 located in the catalytic core of USP7, inhibits its deubiquitinating activity, promotes MDM2 protein degradation, and activates p53 .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
