2449301-27-1
2449301-27-1
Chemical Structure
GSK2643943A
- CAS No.: 2449301-27-1
- Formula:C17H12FN3
- Molecular Weight:277.30
IUPAC Name: (E)-2-amino-6-(3-fluorostyryl)-1H-indole-3-carbonitrile
InChIKey: CGXBPMZRTMXEIA-SNAWJCMRSA-N
SMILES: FC1=CC=CC(/C=C/C2=CC(NC(N)=C3C#N)=C3C=C2)=C1
Biological Activity: GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20. GSK2643943A has affinity with an IC50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC) [1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GSK2643943A | 98.79% | GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20. GSK2643943A has affinity with an IC50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC) . | ||||||||||||||||||||
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GSK2643943A (Standard) | ≥98% | GSK2643943A (Standard) is the analytical standard of GSK2643943A (HY-111458). This product is intended for research and analytical applications. GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20. GSK2643943A has affinity with an IC50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC) . | ||||||||||||||||||||
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References
- [1]. Nishi Kumari, et al. Targeting the Ubiquitin Proteasome System in Cancer. Shahzad, Hafiz Naveed (2018). Neoplasm Targeting the Ubiquitin Proteasome System in Cancer. , 10.5772/intechopen.69560(Chapter 8).
- [2]. Ruitao Lu, et al. USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells. Mol Ther Oncolytics. 2021 Nov 11;23:477-487. [Content Brief]
