1426544-54-8
1426544-54-8
Chemical Structure
HBX 28258
- CAS No.: 1426544-54-8
- Formula:C26H30ClN3O
- Molecular Weight:435.99
IUPAC Name: N-(3-(benzyl(ethyl)amino)propyl)-9-chloro-5,6,7,8-tetrahydroacridine-2-carboxamide
InChIKey: UFUHGICPAGBHCV-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(N=C3C(CCCC3)=C2Cl)C=C1)NCCCN(CC)CC4=CC=CC=C4
Biological Activity: HBX 28258 is a selective USP7 inhibitor, with an IC50 of 22.6 μM. HBX 28258 can covalently binds to Cys223 located in the catalytic core of USP7, inhibits its deubiquitinating activity, promotes MDM2 protein degradation, and activates p53[1].
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HBX 28258 | HBX 28258 is a selective USP7 inhibitor, with an IC50 of 22.6 μM. HBX 28258 can covalently binds to Cys223 located in the catalytic core of USP7, inhibits its deubiquitinating activity, promotes MDM2 protein degradation, and activates p53. | |||||||||||||||||||||
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References
Keywords
