Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
diabete,
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "diabete," in MCE Product Catalog:
10
Target:
Research Areas:
Tolbutamide is an orally active KATP inhibitor. Tolbutamide inhibits cell proliferation, stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete .
2
2 Cited Publications
Synonyms: LY3502970; GLP-1 receptor agonist 1
Target:
Research Areas:
Orforglipron (LY3502970) (Compound 67) is an orally active agonist for Glucagon-like peptide-1 receptor (GLP-1R), which exhibits potency in ameliorates the type 2 diabete .
2
2 Cited Publications
Synonyms: LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate
Target:
Research Areas:
Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate) is the calcium salt hydrate form of Orforglipron (HY-112185). Orforglipron is an orally active agonist for Glucagon-like peptide-1 receptor (GLP-1R), which exhibits potency in ameliorating the type 2 diabete .
Target:
Research Areas:
Tolbutamide (Standard) is the analytical standard of Tolbutamide. This product is intended for research and analytical applications. Tolbutamide is an orally active KATP inhibitor. Tolbutamide inhibits cell proliferation, stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete .
Synonyms: CGT-8012
Target:
Research Areas:
Sheng Gelieting (CGT-8012) is a dipeptidy peptidase-IV enzyme (DP-IV) inhibitor. Sheng Gelieting has great DP-IV inhibition activity with an IC50 value of 87 nM. Sheng Gelieting can be used for curing or preventing diseases relevant to the dipeptidy peptidase-IV enzyme, such as the diabetes, particularly the II-type diabete .
Target:
Research Areas:
SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used in diabete research .
Cat. No.: HY-170409
CAS No.: 1195795-81-3
Target:
Research Areas:
BNN27 is the agonist for TrkA receptor and p75NTR receptor, that exhibits neurotrophic and anti-apoptotic effects. BNN27 increases the levels of glutamate, GABA, and glutamine in the rat hippocampus and prefrontal cortex, improves glutamate turnover. BNN27 exhibits neuroprotective efficacy in mouse amyotrophic lateral sclerosis (ALS) model, exhibits anti-inflammatory efficacy in experimental autoimmune encephalomyelitis (EAE) model, exhibits retinal protective efficacy in rat diabete models. BNN27 is blood-brain barrier penetrable .
Cat. No.: HY-19859
CAS No.: 1163719-08-1
Target:
Research Areas:
AMG-222 (tosylate) is a DPP-IV inhibitor that can be used in the research of type II diabete .
Cat. No.: HY-P4843
CAS No.: 1139691-72-7
Target:
Research Areas:
Cat. No.: HY-170588
CAS No.: 3115340-49-0
Target:
Research Areas:
α-Glucosidase-IN-78 (Compound 12m) is an inhibitor for α-glucosidase with a reversible, competitive IC50 6.0 μM. α-Glucosidase-IN-78 can be used in research of diabete for its hypoglycemic property .
Cat. No.: HY-168329
Research Areas:
TGR5 agonist 7 (Compound 22-Na) is a gut-restricted, orally active agonist for G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC50 < 1 μM. TGR5 agonist 7 exhibits blood glucose lowering effect in mouse model, and can be used in diabete research .
Cat. No.: HY-170582
Target:
Research Areas:
PTP1B-IN-29 (Compound A2B5) is an inhibitor for phosphatase, that inhibits protein tyrosine phosphatase 1B (PTP1B), TCPTP and λPPase with IC50s of 1.27 μM, 4.38 μM and 8.79 μM, respectively. PTP1B-IN-29 can be used in research of diabete and obesity .
Cat. No.: HY-114834
CAS No.: 158234-40-3
Target:
Research Areas:
AHL-157 is a fibrate hypolipidemic agent. AHL-157 can decrease triglyceride, cholesterol, and blood sugar. AHL-157 can be used for the research of metabolic disease, such as hyperlipidemia and diabete .
Cat. No.: HY-W387035
CAS No.: 2799-15-7
Target:
Research Areas:
D-α-Methyl DOPA is an inhibitor of the binding of DQ8 peptide to MHC class II molecules. D-α-Methyl DOPA occupies a pocket along the DQ8 peptide binding groove. D-α-Methyl DOPA inhibits the binding of a DQ8 peptide to an MHC class II molecule for presentation to CD4 + T cells, thereby slowing the development or progression of type 1 diabete or celiac disease .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
