dichloromethane

By Targets:	Biochemical Assay Reagents (4) COX (1) Drug Derivative (2) Ephrin Receptor (1) Interleukin Related (1) Lipoxygenase (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (4) Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-21623

Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct	Biochemical Assay Reagents	Others
Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct is a common dichloromethane solvate of the palladium catalyst Pd(dppf)Cl₂, a phosphine ligand palladium(II) complex, which can be used as a versatile precatalyst for various cross-coupling reactions. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct can stabilize reaction intermediates and lower the reaction activation energy in coupling reactions, and can be used in Suzuki-Miyaura coupling reaction studies .

HY-W002327

Fmoc-Asn(Trt)-OH	Biochemical Assay Reagents	Others
Fmoc-Asn (Trt)-OH is an Fmoc-protected asparagine derivative. Fmoc-Asn (Trt)-OH supports solid-phase peptide synthesis .

HY-N2489

5α-Hydroxy-laxogenin Brassinosteroid BB 16; DI 31	Biochemical Assay Reagents	Others
5α-Hydroxy-laxogenin (Brassinosteroid BB 16; DI 31) is a derivative of laxogenin, a spirostane-type steroid. 5α-Hydroxy-laxogenin serves as a plant-derived anabolic agent and is used as a dietary supplement .

HY-W021358

N,N,N′,N′-Tetramethyl-p-phenylenediamine	Biochemical Assay Reagents	Others
N,N,N′,N′-Tetramethyl-p-phenylenediamine is an electron-donating aromatic diamine with a low ionization potential. N,N,N′,N′-Tetramethyl-p-phenylenediamine is a classic electron donor model compound for photochemical electron transfer studies .

HY-P10579

123B9 1 Publications Verification	Ephrin Receptor	Cancer
123B9, a tumor-homing agent, is a potent and selective EphA2 agonist with a K_d value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors .

HY-133865

Diacetoxy-6-gingerdiol 1 Publications Verification	Interleukin Related	Metabolic Disease Inflammation/Immunology
Diacetoxy-6-gingerdiol is a gingerol isolated with anti-inflammatory and antioxidant effects, which is found in the dichloromethane extract of rhizomes of ginger (Zingiber officinale Roscoe). Diacetoxy-6-gingerdiol protects the extracellular matrix of nucleus pulposus cells and ameliorates intervertebral disc degeneration by inhibiting the IL-1β-mediated NLRP3 pathway .

HY-N1725

2-Desoxy-4-epi-pulchellin	Others	Others
2-Desoxy-4-epi-pulchellin (compound 13) is a compound isolated from dichloromethane-soluble portion of Polygonum hydropiper .

HY-N3935

Gelomulide N	Others	Others
Gelomulide N is a compound that can be isolated from dichloromethane soluble extract of Gelonium aequoreum .

HY-N1827

3-epi-Maslinic acid	Others	Others
3-epi-Maslinic acid is an acidic pentacyclic triterpene isolated from Hexane and dichloromethane extracts of Platostoma africanum P. Beauv .

HY-N7324

Dehydroperilloxin	COX	Inflammation/Immunology
Dehydroperilloxin is a natural compound isolated from the dichloromethane extract of the stems of Perilla frutescens var. acuta. Dehydroperilloxin possesses inhibitory activity against cyclooxygenase-1, with the IC₅₀ value of 30.4 μM .

HY-N16694

6,7-Dehydroferruginol	Lipoxygenase	Others
6,7-Dehydroferruginol is a diterpenoid compound that can be isolated from the dichloromethane extract of Juniperus communis wood. At a concentration of 100 μg/mL, 6,7-Dehydroferruginol showed no inhibitory activity against 12(S)-LOX and did not inhibit the production of 12(S)-HETE .

HY-N19719

Bispyrayafoline	Drug Derivative	Inflammation/Immunology
Bispyrayafoline is a pyrrolidone and antioxidant with an IC₅₀ value of 13.85 μM against DPPH. Bispyrayafoline can be found in the leaves of Murraya koenigii (Linn.) Spreng. Bispyrayafoline's antioxidant activity is concentration-dependent but time-independent. Bispyrayafoline can be utilized in studies concerning oxidative damage .

HY-N11732

O-Demethylrotenone	Drug Derivative	Inflammation/Immunology
O-Demethylrotenone is a rotenone (HY-B1756) derivative and a photodegradation product of rotenone that induces acute intraperitoneal toxicity. The acute intraperitoneal LD₅₀ of O-Demethylrotenone in Mus musculus is 8.0 mg/kg .

Cat. No.	Product Name	Type

HY-21623

Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct	Biochemical Assay Reagents
Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct is a common dichloromethane solvate of the palladium catalyst Pd(dppf)Cl₂, a phosphine ligand palladium(II) complex, which can be used as a versatile precatalyst for various cross-coupling reactions. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct can stabilize reaction intermediates and lower the reaction activation energy in coupling reactions, and can be used in Suzuki-Miyaura coupling reaction studies .

Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct

Biochemical Assay Reagents

Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct is a common dichloromethane solvate of the palladium catalyst Pd(dppf)Cl₂, a phosphine ligand palladium(II) complex, which can be used as a versatile precatalyst for various cross-coupling reactions. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct can stabilize reaction intermediates and lower the reaction activation energy in coupling reactions, and can be used in Suzuki-Miyaura coupling reaction studies .

HY-W002327

Fmoc-Asn(Trt)-OH	Biochemical Assay Reagents
Fmoc-Asn (Trt)-OH is an Fmoc-protected asparagine derivative. Fmoc-Asn (Trt)-OH supports solid-phase peptide synthesis .

Cat. No.	Product Name	Target	Research Area

HY-P10579

123B9 1 Publications Verification	Ephrin Receptor	Cancer
123B9, a tumor-homing agent, is a potent and selective EphA2 agonist with a K_d value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-133865

Diacetoxy-6-gingerdiol 1 Publications Verification	Zingiber officinale Roscoe Monophenols Classification of Application Fields Other Diseases Phenols Plants Disease Research Fields Source Classification Zingiberaceae	Interleukin Related
Diacetoxy-6-gingerdiol is a gingerol isolated with anti-inflammatory and antioxidant effects, which is found in the dichloromethane extract of rhizomes of ginger (Zingiber officinale Roscoe). Diacetoxy-6-gingerdiol protects the extracellular matrix of nucleus pulposus cells and ameliorates intervertebral disc degeneration by inhibiting the IL-1β-mediated NLRP3 pathway .

HY-N1725

2-Desoxy-4-epi-pulchellin	Natural Products Classification of Application Fields Other Diseases Plants Compositae Disease Research Fields Erythrina arborescens Roxb. Source Classification	Others
2-Desoxy-4-epi-pulchellin (compound 13) is a compound isolated from dichloromethane-soluble portion of Polygonum hydropiper .

HY-N3935

Gelomulide N	Triterpenes Terpenoids Yucca gloriosa L. Plants Source Classification Asparagaceae Juss.	Others
Gelomulide N is a compound that can be isolated from dichloromethane soluble extract of Gelonium aequoreum .

HY-N7324

Dehydroperilloxin	Natural Products Labiatae Dicerothamnus rhinocerotis Plants Source Classification	COX
Dehydroperilloxin is a natural compound isolated from the dichloromethane extract of the stems of Perilla frutescens var. acuta. Dehydroperilloxin possesses inhibitory activity against cyclooxygenase-1, with the IC₅₀ value of 30.4 μM .

HY-N16694

6,7-Dehydroferruginol	Structural Classification Juniperus communis L. Cupressaceae Terpenoids Diterpenoids Plants Source Classification	Lipoxygenase
6,7-Dehydroferruginol is a diterpenoid compound that can be isolated from the dichloromethane extract of Juniperus communis wood. At a concentration of 100 μg/mL, 6,7-Dehydroferruginol showed no inhibitory activity against 12(S)-LOX and did not inhibit the production of 12(S)-HETE .

HY-N19719

Bispyrayafoline	Structural Classification Alkaloids Rutaceae Murraya koenigii (L.) Spreng Carbazole Alkaloids Plants Source Classification	Drug Derivative
Bispyrayafoline is a pyrrolidone and antioxidant with an IC₅₀ value of 13.85 μM against DPPH. Bispyrayafoline can be found in the leaves of Murraya koenigii (Linn.) Spreng. Bispyrayafoline's antioxidant activity is concentration-dependent but time-independent. Bispyrayafoline can be utilized in studies concerning oxidative damage .

HY-N11732

O-Demethylrotenone	Structural Classification Natural Products Leguminosae Ketones, Aldehydes, Acids Derris trifoliata Lour. Plants Source Classification	Drug Derivative
O-Demethylrotenone is a rotenone (HY-B1756) derivative and a photodegradation product of rotenone that induces acute intraperitoneal toxicity. The acute intraperitoneal LD₅₀ of O-Demethylrotenone in Mus musculus is 8.0 mg/kg .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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dichloromethane

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