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Cat. No.: HY-187463

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JAK-IN-42

JAK-IN-42 is a JAK inhibitor that can be used in research related to JAK-abnormal diseases, such as rheumatoid arthritis.

For research use only. We do not sell to patients.

CAS No.: 2812383-82-5
Formula: C₂₇H₄₀N₆O₃
Molecular Weight:496.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JAK-IN-42 Chemical Structure

CAS No.: 2812383-82-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

JAK-IN-42 is a JAK inhibitor that can be used in research related to JAK-abnormal diseases, such as rheumatoid arthritis^[1].

All JAK Isoforms :

In Vitro

JAK-IN-42 (Compound I) can be successfully synthesized via a condensation reaction between intermediate j or its salt and cyanoacetic acid under optimized reaction conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2812383-82-5
Molecular Weight 496.64
Formula C₂₇H₄₀N₆O₃
SMILES

O=C(CC#N)N1CC[C@@H](C)[C@@H](N(C2=C(C=CN3COC(CCC(CCCC)CC)=O)C3=NC=N2)C)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li A, et al. Preparation method for JAK inhibitor compound, and crystal form and intermediate of JAK inhibitor compound. WO2026153364A1, WIPO, 2026.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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JAK-IN-42

All JAK Isoforms