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ecdysteroid agonist

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By Targets:	Drug Derivative (1) Endogenous Metabolite (2) Environmental Pollutants (1) FXR (1) Insecticide (2) Reference Standards (2)
By Research Areas:	Cardiovascular Disease (3) Infection (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2548

Turkesterone	Others	Cardiovascular Disease
Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems .

HY-103273

Muristerone A	Endogenous Metabolite	Others
Muristerone A is a phytoecdysteroid analog of ecdysone and a potent agonist of ecdysteroid receptor with a K_d of 1 nM .

HY-113890

Halofenozide RH-0345	Environmental Pollutants	Others
Halofenozide (RH-0345) is an *ecdysteroid* agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone .

HY-118541

RH-5849	Insecticide	Others
RH-5849 is an orally active agonist for non-steroidal ecdysteroid, which inhibits the larval growth of Plodia inferpuncteila in a dose-dependent manner. RH-5849 exhibits molting hormone activity .

HY-N11081

Hexanorcucurbitacin D	FXR	Cardiovascular Disease
Hexanorcucurbitacin D, a cucurbitacin, is a weak ecdysteroid receptor agonist. Hexanorcucurbitacin D can be isolated from Trichosanthes cucumeroides roots. Hexanorcucurbitacin D can be used for the research of cardiovascular disease (CVD) .

HY-N2548R

Turkesterone (Standard)	Reference Standards Others	Cardiovascular Disease
Turkesterone (Standard) is the analytical standard of Turkesterone. This product is intended for research and analytical applications. Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems .

HY-113890R

Halofenozide (Standard) RH-0345 (Standard)	Others Reference Standards	Others
Halofenozide (Standard) is the analytical standard of Halofenozide. This product is intended for research and analytical applications. Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone .

HY-N18079

Dacryhainansterone	Drug Derivative	Others
Dacryhainansterone is an insect ecdysteroid receptor agonist with a pIC₅₀ of 7.64 M.Dacryhainansterone binds to the insect ecdysteroid receptor and activates it in a reporter gene assay .

HY-118989

Ajugalactone	Insecticide Endogenous Metabolite	Infection
Ajugalactone is a phytoecdysteroid found in plants of the Ajuga genus. Ajugalactone shows both ecdysone (HY-N0179) agonist activity and anti‑ponasterone A (HY-N1534) antagonist activity. Ajugalactone significantly disrupts insect molting and developmental processes. Ajugalactone acts as an insect growth regulator that interferes with insect molting. Ajugalactone induces complete mortality in first‑instar larvae of the greenhouse whitefly. Ajugalactone can be used for research on insect‑plant interactions and insect growth regulation .

Turkesterone	Cardiovascular Disease other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	Others
Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems .

Muristerone A	Ipomoea nil (Linnaeus) Roth Classification of Application Fields Other Diseases Plants Convolvulaceae Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Muristerone A is a phytoecdysteroid analog of ecdysone and a potent agonist of ecdysteroid receptor with a K_d of 1 nM .

Hexanorcucurbitacin D	Triterpenes Terpenoids Cucurbitaceae Trichosanthes cucumeroides (Ser.) Maxim. Plants Source Classification	FXR
Hexanorcucurbitacin D, a cucurbitacin, is a weak ecdysteroid receptor agonist. Hexanorcucurbitacin D can be isolated from Trichosanthes cucumeroides roots. Hexanorcucurbitacin D can be used for the research of cardiovascular disease (CVD) .

Turkesterone (Standard)	Structural Classification other families Plants Steroids Source Classification	Reference Standards Others
Turkesterone (Standard) is the analytical standard of Turkesterone. This product is intended for research and analytical applications. Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems .

Dacryhainansterone	Structural Classification Commelinaceae Cyanotis arachnoidea C. B. Clarke Plants Steroids Source Classification	Drug Derivative
Dacryhainansterone is an insect ecdysteroid receptor agonist with a pIC₅₀ of 7.64 M.Dacryhainansterone binds to the insect ecdysteroid receptor and activates it in a reporter gene assay .

Ajugalactone	Structural Classification Labiatae Plants Steroids Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Insecticide Endogenous Metabolite
Ajugalactone is a phytoecdysteroid found in plants of the Ajuga genus. Ajugalactone shows both ecdysone (HY-N0179) agonist activity and anti‑ponasterone A (HY-N1534) antagonist activity. Ajugalactone significantly disrupts insect molting and developmental processes. Ajugalactone acts as an insect growth regulator that interferes with insect molting. Ajugalactone induces complete mortality in first‑instar larvae of the greenhouse whitefly. Ajugalactone can be used for research on insect‑plant interactions and insect growth regulation .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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ecdysteroid agonist

Inhibitors & Agonists

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