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Results for "

furin

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

8

Peptides

2

Recombinant Proteins

1

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1028
    Hexa-D-arginine
    5+ Cited Publications

    furin Inhibitor II

    		 Bacterial Infection
    Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .
    Hexa-D-arginine
  • HY-147140
    BOS-318
    2 Publications Verification

    		 Furin Inflammation/Immunology
    BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC50 value of 1.9 nM. BOS-318 protects ENaC from subsequent activation by neutrophil elastase. BOS-318 can be used for the rsearch for CF lung disease .
    BOS-318
  • HY-P0133
    (Arg) 9

    Nona-L-arginine; Peptide R9

    		 Ser/Thr Protease Neurological Disease
    (Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model .
    (Arg) 9
  • HY-P2469
    Brain Natriuretic Peptide-45, mouse

    BNP-45, mouse

    		 Natriuretic Peptide Receptor (NPR) Cardiovascular Disease
    Brain Natriuretic Peptide-45, mouse (BNP-45, mouse) is a 45-amino-acid peptide derived from the mouse BNP prohormone, which exhibits natriuretic, diuretic, and vasoactive effects. Brain Natriuretic Peptide-45, mouse contains all amino acid residues deemed critical for the biological activity of natriuretic peptides. Brain Natriuretic Peptide-45, mouse possesses hypotensive and diuretic activities .
    Brain Natriuretic Peptide-45, mouse
  • HY-150737
    MI-1851

    		SARS-CoV Infection
    MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity .
    MI-1851
  • HY-110147B
    SSM3 tetraTFA hydrate

    		Furin Infection
    SSM3 tetraTFA hydrate is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA hydrate is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro .
    SSM3 tetraTFA hydrate
  • HY-P1028A
    Hexa-D-arginine TFA
    5+ Cited Publications

    furin Inhibitor II TFA

    		 Bacterial Infection
    Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .
    Hexa-D-arginine TFA
  • HY-P4548
    Boc-Arg-Val-Arg-Arg-AMC hydrochloride

    Boc-RVRR-AMC

    		 Furin Others
    Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin .
    Boc-Arg-Val-Arg-Arg-AMC hydrochloride
  • HY-P5272
    Histatin-3 TFA

    		Bacterial Inflammation/Immunology
    Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM .
    Histatin-3 TFA
  • HY-P3797
    Furin Substrate

    		Furin Cancer
    Furin Substrate is an peptide. Furin Substrate can be used for the research of various biochemical .
    Furin Substrate
  • HY-163738
    Furin-IN-2

    		Furin SARS-CoV Infection
    Furin-IN-2 (compound P3) is a potent inhibitor of furin, with the IC50 of 35 μM. Furin-IN-2 shows antiviral activity .
    Furin-IN-2
  • HY-RS05148
    FURIN Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FURIN Human Pre-designed siRNA Set A contains three designed siRNAs for FURIN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FURIN Human Pre-designed siRNA Set A
    FURIN Human Pre-designed siRNA Set A
  • HY-RS19197
    Furin Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Furin Mouse Pre-designed siRNA Set A contains three designed siRNAs for Furin gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Furin Mouse Pre-designed siRNA Set A
    Furin Mouse Pre-designed siRNA Set A
  • HY-RS25685
    Furin Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Furin Rat Pre-designed siRNA Set A contains three designed siRNAs for Furin gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Furin Rat Pre-designed siRNA Set A
    Furin Rat Pre-designed siRNA Set A
  • HY-110147A
    SSM3 tetraTFA

    		Furin Infection
    SSM3 tetraTFA is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro .
    SSM3 tetraTFA
  • HY-P10150
    IN-2-LF

    		Bacterial Infection
    IN-2-LF is an inhibitor of lethal factor. IN-2-LF also inhibits furin with an IC50 of 2 μM. IN-2-LF enhances protection against anthrax lethal toxin when in combination with D6R .
    IN-2-LF
  • HY-180145
    Furin-IN-3

    		Furin Influenza Virus Infection
    Furin-IN-3 (Compound 9) is a potent and selective proprotein convertase furin inhibitor with a Ki of 12.4 nM. Furin-IN-3 shows a Ki of 278 nM for PC7. Furin-IN-3 shows a significant antiviral effect on the Furin-dependent H7N7 influenza A virus strain SC35M. Furin-IN-3 can inhibit the cleavage and activation of the viral hemagglutinin (HA), prevent the fusion of the viral membrane with the host cell membrane, and thereby inhibit viral replication and proliferation. Furin-IN-3 can be used for the research of infection, such as influenza virus infection .
    Furin-IN-3
  • HY-183626
    TM5614 sodium

    		PAI-1 Ser/Thr Protease Furin MMP Notch Apoptosis Inflammation/Immunology Cancer
    TM5614 sodium is an orally active and specific PAI-1 inhibitor with an IC50 of <6.95 μM. TM5614 sodium blocks the interaction between PAI-1 and serine proteases or LRP-1, and enhances plasmin generation. TM5614 sodium restores macrophage efferocytosis and promotes macrophage polarization. TM5614 sodium alleviates PAI-1-mediated inhibition of Furin, promotes MT1-MMP maturation, activates the NOTCH1 signaling pathway, inhibits proliferation and induces apoptosis. TM5614 sodium promotes skeletal muscle regeneration and alleviates inflammation in a mouse model of skeletal muscle injury. TM5614 sodium can be used in research on skeletal muscle injury-induced inflammation and chronic myeloid leukemia .
    TM5614 sodium

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