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Isoforms Recommended:	CA IX

Results for "

hCA IX

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Akt (1) Antibiotic (2) Apoptosis (12) Autophagy (4) Bacterial (5) Bcl-2 Family (2) c-Met/HGFR (1) Carbonic Anhydrase (81) Caspase (2) CDK (6) COX (2) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (1) Endogenous Metabolite (2) ERK (1) Ferroptosis (1) HDAC (1) Hydroxycarboxylic Acid Receptor (HCAR) (1) Isotope-Labeled Compounds (1) LOX-1 (1) MDM-2/p53 (1) Mitochondrial Metabolism (2) NAMPT (1) NOD-like Receptor (NLR) (1) P-glycoprotein (1) Parasite (1) Reactive Oxygen Species (ROS) (3) Reference Standards (2) VEGFR (5) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (70) Cardiovascular Disease (5) Endocrinology (1) Infection (6) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (5)

By Targets:

Adenosine Receptor (1)

Akt (1)

Antibiotic (2)

Apoptosis (12)

Autophagy (4)

Bacterial (5)

Bcl-2 Family (2)

c-Met/HGFR (1)

Carbonic Anhydrase (81)

Caspase (2)

CDK (6)

COX (2)

Dipeptidyl Peptidase (1)

DNA/RNA Synthesis (1)

Endogenous Metabolite (2)

ERK (1)

Ferroptosis (1)

HDAC (1)

Hydroxycarboxylic Acid Receptor (HCAR) (1)

Isotope-Labeled Compounds (1)

LOX-1 (1)

MDM-2/p53 (1)

Mitochondrial Metabolism (2)

NAMPT (1)

NOD-like Receptor (NLR) (1)

P-glycoprotein (1)

Parasite (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (2)

VEGFR (5)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (70)

Cardiovascular Disease (5)

Endocrinology (1)

Infection (6)

Inflammation/Immunology (4)

Metabolic Disease (4)

Neurological Disease (5)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: GPR109A Protoporphyrinogen IX oxidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0782

Acetazolamide Maximum Cited Publications 13 Publications Verification	Carbonic Anhydrase Autophagy Bacterial	Cardiovascular Disease Cancer
Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC₅₀ of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities .

HY-B0782A

Acetazolamide sodium Maximum Cited Publications 13 Publications Verification	Carbonic Anhydrase Autophagy Bacterial	Infection Cardiovascular Disease Metabolic Disease Cancer
Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC₅₀ of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities .

HY-32004

Coumalic acid	Endogenous Metabolite Parasite Hydroxycarboxylic Acid Receptor (HCAR)	Infection
Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (K_I = 0.073 μM for hCA IX; K_I = 0.083 μM for hCA XII). Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity .

HY-B0782R

Acetazolamide (Standard) Maximum Cited Publications 13 Publications Verification	Reference Standards Carbonic Anhydrase Autophagy Bacterial	Cardiovascular Disease Cancer
Acetazolamide (Standard) is the analytical standard of Acetazolamide. This product is intended for research and analytical applications. Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC₅₀ of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities .

HY-B0782S

Acetazolamide-d3	Carbonic Anhydrase	Cardiovascular Disease
Acetazolamide-d₃ is deuterium labeled Acetazolamide (HY-B0782). Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC₅₀ of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities.

HY-W012168

4-Chloro-3-sulfamoylbenzoic acid	Carbonic Anhydrase	Metabolic Disease
4-Chloro-3-sulfamoylbenzoic acid is a weak inhibitor of human carbonic anhydrase isoforms hCA I, hCA II, hCA IV, and hCA IX, and a synthesis intermediate for carbonic anhydrase inhibitors. 4-Chloro-3-sulfamoylbenzoic acid is the major metabolite of tripamide detected in tissues, urine, and feces of rats and rabbits following Tripamide (HY-106570) administration. 4-Chloro-3-sulfamoylbenzoic acid can be used for the study of carbonic anhydrase inhibition and species differences in drug metabolism .

HY-W044762

5,6-Dihydro-2H-pyran-2-one	Carbonic Anhydrase	Cancer
5,6-Dihydro-2H-pyran-2-one (Compound 1) is a prodrug-type carbonic anhydrase inhibitor. 5,6-Dihydro-2H-pyran-2-one can specifically inhibit the tumor-associated subtype hCA IX and the cytoplasmic subtype hCA I with K_i values of 1.35 and 8.03 μM. 5,6-Dihydro-2H-pyran-2-one can be used for the research on hypoxia-related cancer .

HY-149269

COX-2-IN-30	COX Carbonic Anhydrase LOX-1	Inflammation/Immunology
COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of COX (IC₅₀=49 nM for COX-2, 10.4 μM for COX-1) and 5-LOX (IC₅₀=2.4 μM). COX-2-IN-30 also inhibits transmembrane hCA IX and hCA XII isoform with nanomolar calss K_i values. COX-2-IN-30 exhibits analgesic, anti-inflammatory, and ulcerogenic activities, and does not show acute gastric effect .

HY-146206

HCAIX-IN-1	Carbonic Anhydrase	Cancer
HCAIX-IN-1 (compound 21e) is a potent and selective *HCAIX* inhibitor with K_Is of 694.9, 126.6, 3.3, 9.8 nM for hCA I, hCA II, hCA IX, hCA XII, respectively .

HY-155391

hCA/Wnt/β-catenin-IN-1	Carbonic Anhydrase P-glycoprotein Wnt β-catenin	Cancer
hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of *hCA* (K_i: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity. hCA/Wnt/β-catenin-IN-1 also inhibits Wnt/β-catenin signaling pathway. hCA/Wnt/β-catenin-IN-1 inhibits cancer cell viability, including the NCI/ADR-RES DOX-resistant cell line .

HY-147799

hCA XII/II/IX-IN-1	Carbonic Anhydrase	Cancer
hCA XII/II/IX-IN-1 (Compound 3) is a potent human carbonic anhydrase (hCA) inhibitor with IC₅₀ values of 2.6, 0.004, 0.005 and 0.001 μM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA XII/II/IX-IN-1 shows anticancer activity .

HY-156169

hCAIX/XII-IN-7	Carbonic Anhydrase	Cancer
hCAIX/XII-IN-7 (compound 3e) is a potent hCA IX and XII inhibitor with K_is of 3.2 nM, 9.2 nM, 503.7 nM and 59 nM for hCA I, hCA II, hCA IX and hCA XII, respectively. hCAIX/XII-IN-7 has the potential for hypoxic tumors research .

HY-144641

Carbonic anhydrase inhibitor 7	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with K_is of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively .

HY-144640

Carbonic anhydrase inhibitor 6	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 6 (compound 9b) is a potent inhibitor of human carbonic anhydrase (hCA), with K_is of 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively .

HY-150570

Carbonic anhydrase inhibitor 14	Carbonic Anhydrase CDK	Cancer
Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with K_i values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC₅₀ of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity .

HY-147829

hCAXII-IN-2	Carbonic Anhydrase	Cancer
hCAXII-IN-2 (compound 5i) is a potent *human carbonic anhydrase XII (hCA* XII)** and hCA IX inhibitor with K_i values of 84.2 nM and 268.5 nM, respectively. hCAXII-IN-2 shows less active against hCA I and hCA II .

HY-101136

Dealanylascamycin AT-265	Antibiotic Carbonic Anhydrase Bacterial	Infection
Dealanylascamycin (AT-265) (Compound 2) is a nucleoside antibiotic. AT 265 is a carbonic anhydrase (CA) inhibitor, with K_i values of 167, 65.2, 234, and 143 nM for hCA I, hCA II, hCA IV, and hCA IX respectively. Dealanylascamycin is the active form of Ascamycin (HY-121071). Dealanylascamycin exhibits broad-spectrum antibacterial activity and is effective against pathogenic bacteria such as Xanthomonas citri (MIC = 0.4 μg/mL). Dealanylascamycin has high cytotoxicity .

HY-162063

hCAIX/XII-IN-9	Carbonic Anhydrase	Inflammation/Immunology Cancer
hCAIX/XII-IN-9 (compound 8) is a potent carbonic anhydrase (CA) inhibitor with K_i values of 1658 nM, 184.8 nM, 8.9 nM, 64.8 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively .

HY-179271

CA/HDAC-IN-1	Carbonic Anhydrase HDAC	Cancer
CA/HDAC-IN-1 (Compound 11) is a CA and HDAC inhibitor with K_i values of 7.4 nM, 31.0 nM, and 7.3 nM for hCA II, hCA IX, and hCA XII, respectively, and IC₅₀ values of 0.21 μM and 3.60 μM for HDAC3 and HDAC8, respectively. CA/HDAC-IN-1 has anti-cancer activity against colon cancer, breast cancer, and melanoma .

HY-163268

Carbonic anhydrase inhibitor 18	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 18 (Compound 9) is a human carbonic anhydrase (hCA) isoform inhibitor, with K_is of 604.8, 333.6, 1.9 and 6.7 nM for hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 18 can be used for the research of cancer .

HY-146207

HCAIX-IN-2	Carbonic Anhydrase	Cancer
HCAIX-IN-2 (compound 9d) is a selective carbonic anhydrase inhibitor with the K_i values of 24.6 nM and 45.3 nM for hCA IX and hCA XII, respectively .

HY-172899

Carbonic anhydrase inhibitor 33	Carbonic Anhydrase Apoptosis CDK	Cancer
Carbonic anhydrase inhibitor 33 (11D) is a dual inhibitor of CA (Carbonic anhydrase) IX/XII and CDK6, with K_i values of 19.7 nM and 26.1 nM for hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 33 (11D) induces G1 arrest and apoptosis. Carbonic anhydrase inhibitor 33 (11D) can be used in the research for NSCLC .

HY-149011

CA IX-IN-1	Carbonic Anhydrase	Cancer
CA IX-IN-1 (compound 12g) is an effective and selective inhibitor of hCA IX with IC₅₀ value of 7 nM. CA IX-IN-1 exhibits antitumor activity .

HY-159982

SH7s	Carbonic Anhydrase	Cancer
SH7s is a potent carbonic anhydrases inhibitor, with K_is of 15.9 and 55.2 nM for hCA IX and hCA XII, respectively. SH7s is also a hypoxia-mediated chemo-sensitizing agent in colorectal cancer cells .

HY-150572

CDK2-IN-11	CDK Carbonic Anhydrase	Cancer
CDK2-IN-11 (compound 9d) is a potent CDK2 inhibitor with an IC₅₀ of 6.4 μM, and K_I values of 23.4 nM, 56.3 nM and 44.3 nM for hCA II, hCA IX and hCA XII, respectively. CDK2-IN-11 can be used for researching anticancer .

HY-77036R

Furagin (Standard) Furazidine (Standard); Furazidin (Standard)	Reference Standards Antibiotic Bacterial Carbonic Anhydrase	Infection Cancer
Furagin (Standard) is the analytical standard of Furagin. This product is intended for research and analytical applications. Furagin (Furazidine) is an analogue of Nitrofurantoin (HY-A0090) and has antibacterial activity. Furagin also inhibits human carbonic anhydrases (K_is: 260 and 57 nM for hCA IX and XII, respectively) .

HY-144807

Carbonic anhydrase inhibitor 9	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 9 is a potent carbonic anhydrase (CA) inhibitor with K_is of 56.4 and 56.9 nM for hCA II and IX, respectively. Antiproliferative activity .

HY-146979

*hA2A/hCA* XII modulator 1**	Adenosine Receptor Carbonic Anhydrase	Cancer
hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA_2A adenosine receptor (hA_2AAR) antagonist with K_is of 6.4 nM, 4.819 μM, >30 μM for hA_2AAR, hA₁AR, hA₃AR, respectively. hA2A/hCA XII modulator 1 is a potent *human carbonic anhydrase XII (hCA* XII) inhibitor with K_i*s of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA* XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research .

HY-151472

hCAIX/XII-IN-6	Carbonic Anhydrase	Infection
hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with K_i values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA) .

HY-146007

hCAIX-IN-17	Carbonic Anhydrase	Cancer
hCA IX-IN-1 (Compound 6f) is a human carbonic anhydrase (hCA) inhibitor with K_i values of 331.4, 28.4, 9.4 and 17.8 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA IX-IN-1 shows anticancer activity .

HY-157135

hCAIX-IN-19	Carbonic Anhydrase	Cancer
hCAIX-IN-19 is a sulfonamides inhibitor against hCA IX with an inhibition constant (K_I) of 6.2 nM and show good selectivity over hCA I (hCA I/ hCA IX = 117) .

HY-146008

hCAII-IN-3	Carbonic Anhydrase	Cancer
hCAII-IN-3 (Compound 16) is a human carbonic anhydrase (hCA) inhibitor with K_i values of 403.8, 5.1, 10.2 and 5.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA IX-IN-2 shows anticancer activity .

HY-147828

hCAIX-IN-11	Carbonic Anhydrase	Cancer
hCAIX-IN-11 (Compound 5d) is a selective carbonic anhydrase IX and XII inhibitor with K_i s of 32.7 and 623.5 nM for hCA IX and hCA XII, respectively. hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells .

HY-147827

hCAIX-IN-10	Carbonic Anhydrase	Cancer
hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with K_i s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively. hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells .

HY-163710

hCA/VEGFR-2-IN-5	VEGFR Carbonic Anhydrase	Cancer
hCA/VEGFR-2 IN-5 (compound 9) is an indolone-phenylsulfonamide and a potential dual inhibitor of cancer-related **hCA IX/XII and VEGFR-2. The IC₅₀** values of hCA/VEGFR-2-IN-5 for VEGFR-2, hCA IX and hCA XII are 0.38 μM, 40 and 3.2 nM, respectively. hCA/VEGFR-2-IN-5 has antitumor activity .

HY-155694

hCA/VEGFR-2-IN-1	Carbonic Anhydrase VEGFR	Cancer
hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual Carbonic Anhydrase(CA) IX/XII with K_i values of 4.7 nM and 8.3 nM for hCA XII and hCA IX, respectively. hCA/VEGFR-2-IN-1 (compound 13a) is a potent VEGFR-2 inhibitor with IC₅₀ values 26.3 nM. hCA/VEGFR-2-IN-1 has anticancer activity .

HY-155760

hCA/VEGFR-2-IN-3	VEGFR Carbonic Anhydrase	Cancer
hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-3 inhibits VEGFR-2 (IC₅₀=358 nM), has high binding activity to hCAs with Ki of 4.2 nM (hCA IX), 22.9 nM (hCA II), 25.1 nM (hCA I), 28.0 nM (hCA XII), respectively. hCA/VEGFR-2-IN-3 has antiproliferative activity against VEGFR-2 overexpressing breast cancer cells .

HY-144639

Carbonic anhydrase inhibitor 5	Carbonic Anhydrase	Infection Inflammation/Immunology Cancer
Carbonic anhydrase inhibitor 5 is a potent and selective human carbonic anhydrase (hCA) inhibitor with IC₅₀s of 42.9, 47,6 and 6.7 nM for hCA II, hCA IX and hCA XII, respectively .

HY-146355

hCAII-IN-2	Carbonic Anhydrase	Cancer
hCAII-IN-2 (Compound 11f) is a cytosolic human carbonic anhydrase (hCA) inhibitor with K_i values of 261.4, 3.8, 19.6 and 45.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively .

HY-155763

hCA/VEGFR-2-IN-4	VEGFR Carbonic Anhydrase	Cancer
hCA/VEGFR-2-IN-4 (compound 15b) is an indolinylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-4 inhibits VEGFR-2 (IC₅₀=0.811 μM) and has high binding activity to hCAs, with Ki of 3.8 nM (hCA XII), 6.2 nM (hCA IX), 19.8 nM (hCA II), and 35.5 nM (hCA I), respectively. hCA/VEGFR-2-IN-4 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells .

HY-155758

hCA/VEGFR-2-IN-2	VEGFR Carbonic Anhydrase	Cancer
hCA/VEGFR-2-IN-2 (compound 8g) is an indolinonylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-2 inhibits VEGFR-2 (IC₅₀=204 nM) and has high binding activity to hCAs, with Kis of 3.6 nM (hCA IX), 16.1 nM (hCA II), 16.7 nM (hCA XII), and 75.3 nM (hCA I), respectively. hCA/VEGFR-2-IN-2 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells .

HY-132156

Carbonic anhydrase inhibitor 22	Carbonic Anhydrase	Neurological Disease
Carbonic anhydrase inhibitor 22 (Compd 2g), a sulfonamide carbonic anhydrase inhibitor, with K_i values of 762 nM (hCA I), 20.3 nM (hCA II), 8.3 nM (hCA VII), 17.9 nM (hCA IX) and 10.5 nM (hCA XII), repectively .

HY-168030

hCAIX-IN-23	Apoptosis Ferroptosis Carbonic Anhydrase Reactive Oxygen Species (ROS) Caspase Mitochondrial Metabolism	Cancer
hCAIX-IN-23 (Compound 27) is a human carbonic anhydrase (hCA) inhibitor with K_i values of 10.4 and 8.5 nM for hCA IX and hCA XII, respectively. In addition to inhibiting *hCA* activity, hCAIX-IN-23 releases NO, exhibiting dual antitumor activity. hCAIX-IN-23 induces apoptosis by regulating mitochondrial caspase activity and the ferroptosis pathway (ferroptosis) through the downregulation of hCA IX and iron-regulatory protein expression. hCAIX-IN-23 is useful for renal cancer research .

HY-161374

Carbonic anhydrase inhibitor 20	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 20 (compound 11) is an inhibitor of piperazinosulfonamide carbonic anhydrase (Carbonic Anhydrase). The Ki of Carbonic anhydrase inhibitor 20 for hCA I, hCA II, hCA IX, and hCA XII are 47.6 nM, 36.5 nM, 8.3 nM, and 2.7 nM respectively .

HY-175245

hCA-IN-1	Carbonic Anhydrase	Cancer
hCA-IN-1 (Compound 5u) is an *hCA* inhibitor with K_i values of 159.2, 4.8, 15.5, and 2 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. hCA-IN-1 exhibits broad-spectrum anticancer activity against melanoma, breast, and colon cancer cells. ADME predictions indicate that hCA-IN-1 has good solubility and oral bioavailability. hCA-IN-1 can be used in tumor research .

HY-149329

hCAIX/VII-IN-1	Carbonic Anhydrase	Neurological Disease Cancer
hCAIX/VII-IN-1 is a selective **hCA VII/IX** inhibitor. hCAIX/VII-IN-1 inhibit hCAⅠ, hCAⅡ, hCAⅣ, hCAⅦ and hCAⅨ with K_i values of 336.2 nM,185.8 nM, 1055 nM, 35.6 nM and 28.0 nM, respectively. hCAIX/VII-IN-1 can be used for the research of cancer and neurological diseases .

HY-N2682A

(E)-Dehydrodiconiferyl alcohol	Carbonic Anhydrase	Cancer
(E)-Dehydrodiconiferyl alcohol behaves as good hCA IX and hCA XII dual inhibitors . And (E)-Dehydrodiconiferyl alcohol suppresses the NF-κB nuclear translocation in connective tissue of healing area .

HY-151630

hCAIX-IN-16	Carbonic Anhydrase	Cancer
hCAIX-IN-16 (Compound 12d) is hCA IX inhibitor, with K_{i values of 190.0 and 187.9 nM for hCA IX and hCA XII, respectively. hCAIX-IN-16 can arrest the cell cycle of breast cancer MDA-MB-468 in G0-G1 and S phase and induce apoptosis. hCAIX-IN-16 shows good broad-spectrum anticancer activity and can be used for cancer research .}

HY-152141

hCAII-IN-9	Carbonic Anhydrase	Others
hCAII-IN-9 is a potent carbonic anhydrase inhibitor with IC₅₀s of 1.18 μM (hCA II), 0.17 μM (hCA IX), and 2.99 μM (hCA XII), respectively. hCAII-IN-9 has no blood-brain barrier permeability .

HY-163414

hCAIX/XII-IN-11	Carbonic Anhydrase	Cancer
hCAIX/XII-IN-11 (Compound 6c) is an inhibitor of hCA IX and hCA XII with a K_i value of 0.7 μM for both the isoforms. hCAIX/XII-IN-11 can be used for anticancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-32004

Coumalic acid	Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Smilacis Glabrae Rhizoma Plants Disease Research Fields Source Classification	Endogenous Metabolite Parasite Hydroxycarboxylic Acid Receptor (HCAR)
Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (K_I = 0.073 μM for hCA IX; K_I = 0.083 μM for hCA XII). Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity .

HY-N2682A

(E)-Dehydrodiconiferyl alcohol	Monophenols Glycine soya Classification of Application Fields Lignans Phenols Cyamopsis tetragonoloba (L.) Taub. Phenylpropanoids Plants Compositae Disease Research Fields Cancer Source Classification	Carbonic Anhydrase
(E)-Dehydrodiconiferyl alcohol behaves as good hCA IX and hCA XII dual inhibitors . And (E)-Dehydrodiconiferyl alcohol suppresses the NF-κB nuclear translocation in connective tissue of healing area .

Cat. No.	Product Name	Chemical Structure

HY-B0782S

Acetazolamide-d3
Acetazolamide-d₃ is deuterium labeled Acetazolamide (HY-B0782). Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC₅₀ of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities.

HY-B0782S1

Acetazolamide-13C2,d3
Acetazolamide- ¹³C₂,d₃ is the ¹³C- and deuterium labeled Acetazolamide. Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC₅₀ of 30 nM for hCA IX . Diuretic effects .

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